Seroatlas · Human Serome Atlas

TADA3

Transcriptional adapter 3

Also known as: ADA3, FLJ20221, FLJ21329, hADA3, NGG1, TADA3_HUMAN, TADA3L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75528
Gene
TADA3
Ensembl
ENSG00000171148
Chromosome
3
Canonical length
432 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosomes. The protein encoded by this gene is a transcriptional activator adaptor and a component of the histone acetyl transferase (HAT) coactivator complex which plays a crucial role in chromatin modulation and cell cycle progression. Along with the other components of the complex, this protein links transcriptional activators bound to specific promoters, to histone acetylation and the transcriptional machinery. The protein is also involved in the stabilization and activation of the p53 tumor suppressor protein that plays a role in the cellular response to DNA damage. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013]

Canonical amino-acid sequenceUniProt

432 residues, UniProt reviewed canonical sequence.

>O75528|TADA3
     1  MSELKDCPLQ FHDFKSVDHL KVCPRYTAVL ARSEDDGIGI EELDTLQLEL ETLLSSASRR
    61  LRVLEAETQI LTDWQDKKGD RRFLKLGRDH ELGAPPKHGK PKKQKLEGKA GHGPGPGPGR
   121  PKSKNLQPKI QEYEFTDDPI DVPRIPKNDA PNRFWASVEP YCADITSEEV RTLEELLKPP
   181  EDEAEHYKIP PLGKHYSQRW AQEDLLEEQK DGARAAAVAD KKKGLMGPLT ELDTKDVDAL
   241  LKKSEAQHEQ PEDGCPFGAL TQRLLQALVE ENIISPMEDS PIPDMSGKES GADGASTSPR
   301  NQNKPFSVPH TKSLESRIKE ELIAQGLLES EDRPAEDSED EVLAELRKRQ AELKALSAHN
   361  RTKKHDLLRL AKEEVSRQEL RQRVRMADNE VMDAFRKIMA ARQKKRTPTK KEKDQAWKTL
   421  KERESILKLL DG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TADA3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
75 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 75 nTPM
  • adrenal gland: 74 nTPM
  • skeletal muscle: 74 nTPM
  • amygdala: 73 nTPM
  • basal ganglia: 71 nTPM
  • testis: 67 nTPM

Single-cell type

  • megakaryocytes: 223 nCPM
  • late primary spermatocytes: 163 nCPM
  • late spermatids: 116 nCPM
  • undifferentiated spermatogonia: 110 nCPM
  • decidual stromal cells: 110 nCPM
  • platelets: 87 nCPM

Immune cell

  • eosinophil: 139 nTPM
  • non-classical monocyte: 99 nTPM
  • intermediate monocyte: 76 nTPM
  • basophil: 70 nTPM
  • gdT-cell: 64 nTPM
  • T-reg: 60 nTPM

Brain region

  • thalamus: 85 nTPM
  • medulla oblongata: 77 nTPM
  • hypothalamus: 77 nTPM
  • midbrain: 76 nTPM
  • spinal cord: 73 nTPM
  • basal ganglia: 69 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.87
gnomAD pLI
0
gnomAD missense Z
2.12
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Histone acetyltransferases subunit 3
  • Histone acetyltransferases subunit 3

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TADA3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TADA3 as an antibody target. Whether an autoantibody or antibody against TADA3 could matter depends on whether native TADA3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TADA3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TADA3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TADA3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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