Seroatlas · Human Serome Atlas

SUPT20H

Transcription factor SPT20 homolog

Also known as: bA421P11.4, C13orf19, FAM48A, P38IP, SP20H_HUMAN, SPT20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NEM7
Gene: SUPT20H
Ensembl: ENSG00000102710
Chromosome: 13
Canonical length: 779 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within positive regulation of gluconeogenesis and positive regulation of transcription by RNA polymerase II. Part of SAGA-type complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

779 residues, UniProt reviewed canonical sequence.

>Q8NEM7|SUPT20H
     1  MQQALELALD RAEYVIESAR QRPPKRKYLS SGRKSVFQKL YDLYIEECEK EPEVKKLRRN
    61  VNLLEKLVMQ ETLSCLVVNL YPGNEGYSLM LRGKNGSDSE TIRLPYEEGE LLEYLDAEEL
   121  PPILVDLLEK SQVNIFHCGC VIAEIRDYRQ SSNMKSPGYQ SRHILLRPTM QTLICDVHSI
   181  TSDNHKWTQE DKLLLESQLI LATAEPLCLD PSIAVTCTAN RLLYNKQKMN TRPMKRCFKR
   241  YSRSSLNRQQ DLSHCPPPPQ LRLLDFLQKR KERKAGQHYD LKISKAGNCV DMWKRSPCNL
   301  AIPSEVDVEK YAKVEKSIKS DDSQPTVWPA HDVKDDYVFE CEAGTQYQKT KLTILQSLGD
   361  PLYYGKIQPC KADEESDSQM SPSHSSTDDH SNWFIIGSKT DAERVVNQYQ ELVQNEAKCP
   421  VKMSHSSSGS ASLSQVSPGK ETDQTETVSV QSSVLGKGVK HRPPPIKLPS SSGNSSSGNY
   481  FTPQQTSSFL KSPTPPPSSK PSSIPRKSSV DLNQVSMLSP AALSPASSSQ RTTATQVMAN
   541  SAGLNFINVV GSVCGAQALM SGSNPMLGCN TGAITPAGIN LSGLLPSGGL LPNALPSAMQ
   601  AASQAGVPFG LKNTSSLRPL NLLQLPGGSL IFNTLQQQQQ QLSQFTPQQP QQPTTCSPQQ
   661  PGEQGSEQGS TSQEQALSAQ QAAVINLTGV GSFMQSQAAV LSQLGSAENR PEQSLPQQRF
   721  QLSSAFQQQQ QQIQQLRFLQ HQMAMAAAAA QTAQLHHHRH TGSQSKSKMK RGTPTTPKF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT20H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 53 nTPM

Expression across tissuesHPA

Tissue

testis: 53 nTPM
thymus: 22 nTPM
bone marrow: 18 nTPM
colon: 16 nTPM
cervix: 16 nTPM
urinary bladder: 15 nTPM

Single-cell type

late primary spermatocytes: 529 nCPM
neutrophils: 165 nCPM
early primary spermatocytes: 160 nCPM
lactotrophs: 137 nCPM
somatotrophs: 128 nCPM
corticotrophs: 123 nCPM

Immune cell

neutrophil: 28 nTPM
eosinophil: 22 nTPM
T-reg: 21 nTPM
intermediate monocyte: 21 nTPM
naive CD4 T-cell: 21 nTPM
non-classical monocyte: 20 nTPM

Brain region

cerebellum: 16 nTPM
white matter: 16 nTPM
choroid plexus: 15 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 13 nTPM
midbrain: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.81
gnomAD pLI: 0
gnomAD missense Z: 1.18
DepMap mean gene effect: -0.11
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coregulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUPT20H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT20H as an antibody target. Whether an autoantibody or antibody against SUPT20H could matter depends on whether native SUPT20H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT20H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUPT20H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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