Seroatlas · Human Serome Atlas

SUPT3H

Transcription initiation protein SPT3 homolog

Also known as: SPT3, SPT3L, SUPT3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75486
Gene: SUPT3H
Ensembl: ENSG00000196284
Chromosome: 6
Canonical length: 317 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SAGA complex and transcription factor TFTC complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>O75486|SUPT3H
     1  MNNTAASPMS TATSSSGRST GKSISFATEL QSMMYSLGDA RRPLHETAVL VEDVVHTQLI
    61  NLLQQAAEVS QLRGARVITP EDLLFLMRKD KKKLRRLLKY MFIRDYKSKI VKGIDEDDLL
   121  EDKLSGSNNA NKRQKIAQDF LNSIDQTGEL LAMFEDDEID EVKQERMERA ERQTRIMDSA
   181  QYAEFCESRQ LSFSKKASKF RDWLDCSSME IKPNVVAMEI LAYLAYETVA QLVDLALLVR
   241  QDMVTKAGDP FSHAISATFI QYHNSAESTA ACGVEAHSDA IQPCHIREAI RRYSHRIGPL
   301  SPFTNAYRRN GMAFLAC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SUPT3H can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 8.1 nTPM

Expression across tissuesHPA

Tissue

testis: 8.1 nTPM
salivary gland: 6.7 nTPM
ovary: 5 nTPM
adrenal gland: 4.7 nTPM
spinal cord: 4.2 nTPM
thyroid gland: 4.2 nTPM

Single-cell type

pituitary stem cells: 448 nCPM
adrenal cortex cells: 405 nCPM
brain excitatory neurons: 386 nCPM
retinal ganglion cells: 367 nCPM
brain inhibitory neurons: 364 nCPM
rod photoreceptor cells: 363 nCPM

Immune cell

naive CD4 T-cell: 5.2 nTPM
MAIT T-cell: 5.1 nTPM
memory CD4 T-cell: 4.4 nTPM
naive CD8 T-cell: 4.3 nTPM
plasmacytoid DC: 3.9 nTPM
memory CD8 T-cell: 3.4 nTPM

Brain region

thalamus: 25 nTPM
cerebral cortex: 24 nTPM
white matter: 24 nTPM
cerebellum: 23 nTPM
hypothalamus: 22 nTPM
medulla oblongata: 22 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.26
gnomAD pLI: 0
gnomAD missense Z: 0.11
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SUPT3H in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SUPT3H as an antibody target. Whether an autoantibody or antibody against SUPT3H could matter depends on whether native SUPT3H is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SUPT3H is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SUPT3H as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...