Seroatlas · Human Serome Atlas

YEATS2

YEATS domain-containing protein 2

Also known as: FLJ10201, FLJ12841, FLJ13308, KIAA1197, YETS2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9ULM3
Gene: YEATS2
Ensembl: ENSG00000163872
Chromosome: 3
Canonical length: 1422 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Summary: The protein encoded by this gene is a scaffolding subunit of the ATAC complex, which is a complex with acetyltransferase activity on histones H3 and H4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2017]

Canonical amino-acid sequenceUniProt

1422 residues, UniProt reviewed canonical sequence.

>Q9ULM3|YEATS2
     1  MSGIKRTIKE TDPDYEDVSV ALPNKRHKAI ENSARDAAVQ KIETIIKEQF ALEMKNKEHE
    61  IEVIDQRLIE ARRMMDKLRA CIVANYYASA GLLKVSEGSK TCDTMVFNHP AIKKFLESPS
   121  RSSSPANQRA ETPSANHSES DSLSQHNDFL SDKDNNSNMD IEERLSNNME QRPSRNTGRD
   181  TSRITGSHKT EQRNADLTDE TSRLFVKKTI VVGNVSKYIP PDKREENDQS THKWMVYVRG
   241  SRREPSINHF VKKVWFFLHP SYKPNDLVEV REPPFHLTRR GWGEFPVRVQ VHFKDSQNKR
   301  IDIIHNLKLD RTYTGLQTLG AETVVDVELH RHSLGEDCIY PQSSESDISD APPSLPLTIP
   361  APVKASSPIK QSHEPVPDTS VEKGFPASTE AERHTPFYAL PSSLERTPTK MTTSQKVTFC
   421  SHGNSAFQPI ASSCKIVPQS QVPNPESPGK SFQPITMSCK IVSGSPISTP SPSPLPRTPT
   481  STPVHVKQGT AGSVINNPYV IMDKQPGQVI GATTPSTGSP TNKISTASQV SQGTGSPVPK
   541  IHGSSFVTST VKQEDSLFAS MPPLCPIGSH PKVQSPKPIT GGLGAFTKVI IKQEPGEAPH
   601  VPATGAASQS PLPQYVTVKG GHMIAVSPQK QVITPGEGIA QSAKVQPSKV VGVPVGSALP
   661  STVKQAVAIS GGQILVAKAS SSVSKAVGPK QVVTQGVAKA IVSGGGGTIV AQPVQTLTKA
   721  QVTAAGPQKS GSQGSVMATL QLPATNLANL ANLPPGTKLY LTTNSKNPSG KGKLLLIPQG
   781  AILRATNNAN LQSGSAASGG SGAGGGGGGG GGGGSGSGGG GSTGGGGGTA GGGTQSTAGP
   841  GGISQHLTYT SYILKQTPQG TFLVGQPSPQ TSGKQLTTGS VVQGTLGVST SSAQGQQTLK
   901  VISGQKTTLF TQAAHGGQAS LMKISDSTLK TVPATSQLSK PGTTMLRVAG GVITTATSPA
   961  VALSANGPAQ QSEGMAPVSS STVSSVTKTS GQQQVCVSQA TVGTCKAATP TVVSATSLVP
  1021  TPNPISGKAT VSGLLKIHSS QSSPQQAVLT IPSQLKPLSV NTSGGVQTIL MPVNKVVQSF
  1081  STSKPPAILP VAAPTPVVPS SAPAAVAKVK TEPETPGPSC LSQEGQTAVK TEESSELGNY
  1141  VIKIDHLETI QQLLTAVVKK IPLITAKSED ASCFSAKSVE QYYGWNIGKR RAAEWQRAMT
  1201  MRKVLQEILE KNPRFHHLTP LKTKHIAHWC RCHGYTPPDP ESLRNDGDSI EDVLTQIDSE
  1261  PECPSSFSSA DNLCRKLEDL QQFQKREPEN EEEVDILSLS EPVKINIKKE QEEKQEEVKF
  1321  YLPPTPGSEF IGDVTQKIGI TLQPVALHRN VYASVVEDMI LKATEQLVND ILRQALAVGY
  1381  QTASHNRIPK EITVSNIHQA ICNIPFLDFL TNKHMGILNE DQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YEATS2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

thymus: 16 nTPM
retina: 15 nTPM
bone marrow: 14 nTPM
cerebellum: 14 nTPM
ovary: 13 nTPM
lymph node: 12 nTPM

Single-cell type

alveolar cells type 1: 261 nCPM
retinal ganglion cells: 143 nCPM
retinal bipolar cells: 128 nCPM
lactotrophs: 124 nCPM
rod photoreceptor cells: 123 nCPM
thyrotrophs: 123 nCPM

Immune cell

neutrophil: 8.5 nTPM
non-classical monocyte: 7.2 nTPM
classical monocyte: 4.6 nTPM
plasmacytoid DC: 2.1 nTPM
intermediate monocyte: 2 nTPM
gdT-cell: 1.9 nTPM

Brain region

cerebellum: 39 nTPM
cerebral cortex: 39 nTPM
white matter: 37 nTPM
basal ganglia: 34 nTPM
hypothalamus: 34 nTPM
amygdala: 32 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YEATS2.

Disease | AllUniProt

Conditions YEATS2 is implicated in, by any mechanism.

Epilepsy, familial adult myoclonic, 4 (FAME4) MIM:615127

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.28
gnomAD pLI: 1
gnomAD missense Z: 0.97
DepMap mean gene effect: -0.52
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

YEATS
YEATS superfamily
YEATS domain
YEATS family
YEATS domain-containing protein 2, three-helical bundle domain
Three-helical bundle domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YEATS2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YEATS2 as an antibody target. Whether an autoantibody or antibody against YEATS2 could matter depends on whether native YEATS2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YEATS2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YEATS2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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