Seroatlas · Human Serome Atlas

KRT27

Keratin, type I cytoskeletal 27

Also known as: K1C27_HUMAN, KRT25C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q7Z3Y8
Gene
KRT27
Ensembl
ENSG00000171446
Chromosome
17
Canonical length
459 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene encodes a member of the type I (acidic) keratin family, which belongs to the superfamily of intermediate filament (IF) proteins. Keratins are heteropolymeric structural proteins which form the intermediate filament. These filaments, along with actin microfilaments and microtubules, compose the cytoskeleton of epithelial cells. The type I keratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2009]

Canonical amino-acid sequenceUniProt

459 residues, UniProt reviewed canonical sequence.

>Q7Z3Y8|KRT27
     1  MSVRFSSTSR RLGSCGGTGS VRLSSGGAGF GAGNTCGVPG IGSGFSCAFG GSSSAGGYGG
    61  GLGGGSASCA AFTGNEHGLL SGNEKVTMQN LNDRLASYLE NVRALEEANA DLEQKIKGWY
   121  EKFGPGSCRG LDHDYSRYFP IIDELKNQII SATTSNAHVV LQNDNARLTA DDFRLKFENE
   181  LALHQSVEAD INGLRRVLDE LTLCRTDLEI QLETLSEELA YLKKNHEEEM KALQCAAGGN
   241  VNVEMNAAPG VDLTVLLNNM RAEYEALAEQ NRRDAEAWFN EKSASLQQQI SDDAGATTSA
   301  RNELIEMKRT LQTLEIELQS LLATKHSLEC SLTETESNYC AQLAQIQAQI GALEEQLHQV
   361  RTETEGQKLE YEQLLDIKVH LEKEIETYCL LIDGEDGSCS KSKGYGGPGN QTKDSSKTTI
   421  VKTVVEEIDP RGKVLSSRVH TVEEKSTKVN NKNEQRVSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against KRT27 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
65 nTPM

Expression across tissuesHPA

Tissue

  • skin: 65 nTPM
  • adipose tissue: 1.4 nTPM
  • salivary gland: 1 nTPM
  • breast: 0.9 nTPM
  • testis: 0.2 nTPM
  • gallbladder: 0.1 nTPM

Single-cell type

  • ocular epithelial cells: 12 nCPM
  • melanocytes: 8.1 nCPM
  • undifferentiated spermatogonia: 3.6 nCPM
  • epididymal basal cells: 3.4 nCPM
  • alveolar cells type 2: 3 nCPM
  • medullary thymic epithelial cells: 2.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • hypothalamus: 0.2 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM
  • choroid plexus: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.09
gnomAD pLI
0
gnomAD missense Z
-0.04
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of KRT27 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads KRT27 as an antibody target. Whether an autoantibody or antibody against KRT27 could matter depends on whether native KRT27 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

KRT27 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label KRT27 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/KRT27. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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