Seroatlas · Human Serome Atlas

TADA1

Transcriptional adapter 1

Also known as: ADA1, hADA1, HFI1, STAF42, TADA1_HUMAN, TADA1L

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96BN2
Gene: TADA1
Ensembl: ENSG00000152382
Chromosome: 1
Canonical length: 335 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Focal adhesion sites,Cytosol

OverviewNCBI Gene

TADA1L is a protein subunit of the human STAGA complex (SPT3; (MIM 602947)/TAF9 (MIM 600822)/GCN5 (MIM 602301) acetyltransferase complex), which is a chromatin-modifying multiprotein complex (Martinez et al., 2001 [PubMed 11564863]).[supplied by OMIM, Apr 2009]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q96BN2|TADA1
     1  MATFVSELEA AKKNLSEALG DNVKQYWANL KLWFKQKISK EEFDLEAHRL LTQDNVHSHN
    61  DFLLAILTRC QILVSTPDGA GSLPWPGGSA AKPGKPKGKK KLSSVRQKFD HRFQPQNPLS
   121  GAQQFVAKDP QDDDDLKLCS HTMMLPTRGQ LEGRMIVTAY EHGLDNVTEE AVSAVVYAVE
   181  NHLKDILTSV VSRRKAYRLR DGHFKYAFGS NVTPQPYLKN SVVAYNNLIE SPPAFTAPCA
   241  GQNPASHPPP DDAEQQAALL LACSGDTLPA SLPPVNMYDL FEALQVHREV IPTHTVYALN
   301  IERIITKLWH PNHEELQQDK VHRQRLAAKE GLLLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TADA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

liver: 25 nTPM
bone marrow: 18 nTPM
retina: 16 nTPM
cerebral cortex: 14 nTPM
thymus: 12 nTPM
cerebellum: 12 nTPM

Single-cell type

oocytes: 46 nCPM
cone photoreceptor cells: 35 nCPM
hepatocytes: 33 nCPM
myonuclei: 27 nCPM
gonadotrophs: 25 nCPM
epicardial cells: 25 nCPM

Immune cell

naive CD4 T-cell: 28 nTPM
NK-cell: 28 nTPM
total PBMC: 25 nTPM
memory CD8 T-cell: 24 nTPM
T-reg: 24 nTPM
MAIT T-cell: 23 nTPM

Brain region

white matter: 17 nTPM
basal ganglia: 15 nTPM
cerebral cortex: 14 nTPM
cerebellum: 14 nTPM
hypothalamus: 13 nTPM
spinal cord: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.09
gnomAD missense Z: 0.8
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 14% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transcription coactivator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transcriptional coactivator Hfi1/Transcriptional adapter 1
Transcriptional regulator of RNA polII, SAGA, subunit

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TADA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TADA1 as an antibody target. Whether an autoantibody or antibody against TADA1 could matter depends on whether native TADA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TADA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TADA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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