Seroatlas · Human Serome Atlas

BECN1

Beclin-1

Also known as: ATG6, BECN1_HUMAN, VPS30

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q14457
Gene
BECN1
Ensembl
ENSG00000126581
Chromosome
17
Canonical length
450 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Nuclear bodies,Cytosol

OverviewNCBI Gene

This gene encodes a protein that regulates autophagy, a catabolic process of degradation induced by starvation. The encoded protein is a component of the phosphatidylinositol-3-kinase (PI3K) complex which mediates vesicle-trafficking processes. This protein is thought to play a role in multiple cellular processes, including tumorigenesis, neurodegeneration and apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

Canonical amino-acid sequenceUniProt

450 residues, UniProt reviewed canonical sequence.

>Q14457|BECN1
     1  MEGSKTSNNS TMQVSFVCQR CSQPLKLDTS FKILDRVTIQ ELTAPLLTTA QAKPGETQEE
    61  ETNSGEEPFI ETPRQDGVSR RFIPPARMMS TESANSFTLI GEASDGGTME NLSRRLKVTG
   121  DLFDIMSGQT DVDHPLCEEC TDTLLDQLDT QLNVTENECQ NYKRCLEILE QMNEDDSEQL
   181  QMELKELALE EERLIQELED VEKNRKIVAE NLEKVQAEAE RLDQEEAQYQ REYSEFKRQQ
   241  LELDDELKSV ENQMRYAQTQ LDKLKKTNVF NATFHIWHSG QFGTINNFRL GRLPSVPVEW
   301  NEINAAWGQT VLLLHALANK MGLKFQRYRL VPYGNHSYLE SLTDKSKELP LYCSGGLRFF
   361  WDNKFDHAMV AFLDCVQQFK EEVEKGETRF CLPYRMDVEK GKIEDTGGSG GSYSIKTQFN
   421  SEEQWTKALK FMLTNLKWGL AWVSSQFYNK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BECN1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
90 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 90 nTPM
  • tongue: 72 nTPM
  • colon: 66 nTPM
  • rectum: 61 nTPM
  • heart muscle: 55 nTPM
  • duodenum: 53 nTPM

Single-cell type

  • esophageal apical cells: 117 nCPM
  • kupffer cells: 100 nCPM
  • neutrophils: 95 nCPM
  • esophageal suprabasal cells: 86 nCPM
  • parietal cells: 81 nCPM
  • goblet cells: 70 nCPM

Immune cell

  • neutrophil: 192 nTPM
  • T-reg: 181 nTPM
  • total PBMC: 172 nTPM
  • basophil: 154 nTPM
  • intermediate monocyte: 152 nTPM
  • non-classical monocyte: 145 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • hypothalamus: 29 nTPM
  • thalamus: 29 nTPM
  • spinal cord: 28 nTPM
  • cerebral cortex: 28 nTPM
  • white matter: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.35
gnomAD pLI
0.94
gnomAD missense Z
1.88
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BECN1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BECN1 as an antibody target. Whether an autoantibody or antibody against BECN1 could matter depends on whether native BECN1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BECN1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BECN1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BECN1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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