Seroatlas · Human Serome Atlas

ENY2

Transcription and mRNA export factor ENY2

Also known as: DC6, ENY2_HUMAN, FLJ20480, Sus1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NPA8
Gene: ENY2
Ensembl: ENSG00000120533
Chromosome: 8
Canonical length: 101 aa
Protein class: Predicted intracellular proteins, Transporters
Subcellular location: Nucleoplasm,Mitochondria

OverviewNCBI Gene

Enables transcription coactivator activity. Involved in poly(A)+ mRNA export from nucleus; positive regulation of DNA-templated transcription; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleoplasm. Part of SAGA complex and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

101 residues, UniProt reviewed canonical sequence.

>Q9NPA8|ENY2
     1  MVVSKMNKDA QMRAAINQKL IETGERERLK ELLRAKLIEC GWKDQLKAHC KEVIKEKGLE
    61  HVTVDDLVAE ITPKGRALVP DSVKKELLQR IRTFLAQHAS L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ENY2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 94 nTPM

Expression across tissuesHPA

Tissue

liver: 94 nTPM
bone marrow: 83 nTPM
choroid plexus: 70 nTPM
kidney: 69 nTPM
skeletal muscle: 68 nTPM
tongue: 64 nTPM

Single-cell type

oocytes: 691 nCPM
gastric progenitor cells: 491 nCPM
megakaryocytes: 439 nCPM
hepatocytes: 423 nCPM
extravillous trophoblasts: 343 nCPM
hofbauer cells: 342 nCPM

Immune cell

non-classical monocyte: 122 nTPM
intermediate monocyte: 113 nTPM
classical monocyte: 103 nTPM
myeloid DC: 94 nTPM
eosinophil: 94 nTPM
plasmacytoid DC: 81 nTPM

Brain region

choroid plexus: 23 nTPM
hypothalamus: 22 nTPM
medulla oblongata: 20 nTPM
white matter: 18 nTPM
midbrain: 17 nTPM
pons: 17 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.44
gnomAD pLI: 0.87
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.63
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 17% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

Transcription factor, enhancer of yellow 2
Transcription factor EnY2 superfamily
Transcription factor e(y)2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ENY2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ENY2 as an antibody target. Whether an autoantibody or antibody against ENY2 could matter depends on whether native ENY2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ENY2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ENY2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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