Seroatlas · Human Serome Atlas

SNRPG

Small nuclear ribonucleoprotein G

Also known as: RUXG_HUMAN, Sm-G

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P62308
Gene: SNRPG
Ensembl: ENSG00000143977
Chromosome: 2
Canonical length: 76 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

The protein encoded by this gene is a component of the U1, U2, U4, and U5 small nuclear ribonucleoprotein complexes, precursors of the spliceosome. The encoded protein may also be a part of the U7 small nuclear ribonucleoprotein complex, which participates in the processing of the 3' end of histone transcripts. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

76 residues, UniProt reviewed canonical sequence.

>P62308|SNRPG
     1  MSKAHPPELK KFMDKKLSLK LNGGRHVQGI LRGFDPFMNL VIDECVEMAT SGQQNNIGMV
    61  VIRGNSIIML EALERV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SNRPG can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 130 nTPM

Expression across tissuesHPA

Tissue

thymus: 130 nTPM
choroid plexus: 117 nTPM
bone marrow: 111 nTPM
heart muscle: 100 nTPM
epididymis: 97 nTPM
lymph node: 94 nTPM

Single-cell type

extravillous trophoblasts: 802 nCPM
migrating cytotrophoblasts: 786 nCPM
cytotrophoblasts: 670 nCPM
esophageal basal cells: 564 nCPM
gastric progenitor cells: 522 nCPM
syncytiotrophoblasts: 461 nCPM

Immune cell

plasmacytoid DC: 274 nTPM
total PBMC: 265 nTPM
T-reg: 231 nTPM
non-classical monocyte: 224 nTPM
intermediate monocyte: 220 nTPM
memory B-cell: 210 nTPM

Brain region

white matter: 42 nTPM
choroid plexus: 37 nTPM
medulla oblongata: 35 nTPM
spinal cord: 35 nTPM
thalamus: 35 nTPM
hypothalamus: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.8
gnomAD missense Z: 1.54
DepMap mean gene effect: -2.06
DepMap dependency class: pan

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SNRPG in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SNRPG as an antibody target. Whether an autoantibody or antibody against SNRPG could matter depends on whether native SNRPG is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SNRPG is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SNRPG as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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