Seroatlas · Human Serome Atlas

PPP1CC

Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

Also known as: PP1C, PP1G_HUMAN, PP1gamma

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P36873
Gene
PPP1CC
Ensembl
ENSG00000186298
Chromosome
12
Canonical length
323 aa
Protein class
Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the protein phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Canonical amino-acid sequenceUniProt

323 residues, UniProt reviewed canonical sequence.

>P36873|PPP1CC
     1  MADLDKLNID SIIQRLLEVR GSKPGKNVQL QENEIRGLCL KSREIFLSQP ILLELEAPLK
    61  ICGDIHGQYY DLLRLFEYGG FPPESNYLFL GDYVDRGKQS LETICLLLAY KIKYPENFFL
   121  LRGNHECASI NRIYGFYDEC KRRYNIKLWK TFTDCFNCLP IAAIVDEKIF CCHGGLSPDL
   181  QSMEQIRRIM RPTDVPDQGL LCDLLWSDPD KDVLGWGEND RGVSFTFGAE VVAKFLHKHD
   241  LDLICRAHQV VEDGYEFFAK RQLVTLFSAP NYCGEFDNAG AMMSVDETLM CSFQILKPAE
   301  KKKPNATRPV TPPRGMITKQ AKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1CC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.26
Highest tissue expression
182 nTPM

Expression across tissuesHPA

Tissue

  • duodenum: 182 nTPM
  • tongue: 164 nTPM
  • skeletal muscle: 148 nTPM
  • small intestine: 139 nTPM
  • testis: 133 nTPM
  • lymph node: 130 nTPM

Single-cell type

  • late spermatids: 1,272 nCPM
  • late primary spermatocytes: 843 nCPM
  • early spermatids: 574 nCPM
  • esophageal apical cells: 352 nCPM
  • enterocytes: 287 nCPM
  • extravillous trophoblasts: 246 nCPM

Immune cell

  • eosinophil: 55 nTPM
  • basophil: 38 nTPM
  • non-classical monocyte: 35 nTPM
  • classical monocyte: 33 nTPM
  • myeloid DC: 33 nTPM
  • memory B-cell: 32 nTPM

Brain region

  • cerebellum: 68 nTPM
  • hypothalamus: 68 nTPM
  • white matter: 64 nTPM
  • thalamus: 60 nTPM
  • midbrain: 60 nTPM
  • basal ganglia: 56 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.34
gnomAD pLI
0.96
gnomAD missense Z
3.36
DepMap mean gene effect
-0.19
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1CC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1CC as an antibody target. Whether an autoantibody or antibody against PPP1CC could matter depends on whether native PPP1CC is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1CC is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1CC as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1CC. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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