Seroatlas · Human Serome Atlas

PPP1R9B

Neurabin-2

Also known as: NEB2_HUMAN, PPP1R6, PPP1R9, SPINO, Spn

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96SB3
Gene: PPP1R9B
Ensembl: ENSG00000108819
Chromosome: 17
Canonical length: 817 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homotetramer

OverviewNCBI Gene

This gene encodes a scaffold protein that functions as a regulatory subunit of protein phosphatase 1a. Expression of this gene is particularly high in dendritic spines, suggesting that the encoded protein may play a role in receiving signals from the central nervous system. The encoded protein has putative tumor suppressor function and decreased expression has been observed in tumors. [provided by RefSeq, Feb 2014]

Canonical amino-acid sequenceUniProt

817 residues, UniProt reviewed canonical sequence.

>Q96SB3|PPP1R9B
     1  MMKTEPRGPG GPLRSASPHR SAYEAGIQAL KPPDAPGPDE APKGAHHKKY GSNVHRIKSM
    61  FLQMGTTAGP SGEAGGGAGL AEAPRASERG VRLSLPRASS LNENVDHSAL LKLGTSVSER
   121  VSRFDSKPAP SAQPAPPPHP PSRLQETRKL FERSAPAAAG GDKEAAARRL LRQERAGLQD
   181  RKLDVVVRFN GSTEALDKLD ADAVSPTVSQ LSAVFEKADS RTGLHRGPGL PRAAGVPQVN
   241  SKLVSKRSRV FQPPPPPPPA PSGDAPAEKE RCPAGQQPPQ HRVAPARPPP KPREVRKIKP
   301  VEVEESGESE AESAPGEVIQ AEVTVHAALE NGSTVATAAS PAPEEPKAQA APEKEAAAVA
   361  PPERGVGNGR APDVAPEEVD ESKKEDFSEA DLVDVSAYSG LGEDSAGSAL EEDDEDDEED
   421  GEPPYEPESG CVEIPGLSEE EDPAPSRKIH FSTAPIQVFS TYSNEDYDRR NEDVDPMAAS
   481  AEYELEKRVE RLELFPVELE KDSEGLGISI IGMGAGADMG LEKLGIFVKT VTEGGAAHRD
   541  GRIQVNDLLV EVDGTSLVGV TQSFAASVLR NTKGRVRFMI GRERPGEQSE VAQLIQQTLE
   601  QERWQREMME QRYAQYGEDD EETGEYATDE DEELSPTFPG GEMAIEVFEL AENEDALSPV
   661  DMEPEKLVHK FKELQIKHAV TEAEIQQLKR KLQSLEQEKG RWRVEKAQLE QSVEENKERM
   721  EKLEGYWGEA QSLCQAVDEH LRETQAQYQA LERKYSKAKR LIKDYQQKEI EFLKKETAQR
   781  RVLEESELAR KEEMDKLLDK ISELEGNLQT LRNSNST

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R9B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 107 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 107 nTPM
hippocampal formation: 106 nTPM
amygdala: 91 nTPM
cerebellum: 82 nTPM
basal ganglia: 70 nTPM
spleen: 49 nTPM

Single-cell type

kupffer cells: 61 nCPM
monocytes: 48 nCPM
neutrophils: 40 nCPM
hofbauer cells: 40 nCPM
monocyte progenitors: 38 nCPM
macrophages: 32 nCPM

Immune cell

basophil: 4.2 nTPM
neutrophil: 4.1 nTPM
eosinophil: 2.9 nTPM
NK-cell: 2.2 nTPM
naive B-cell: 2 nTPM
non-classical monocyte: 2 nTPM

Brain region

cerebral cortex: 227 nTPM
hippocampal formation: 217 nTPM
amygdala: 155 nTPM
basal ganglia: 144 nTPM
thalamus: 130 nTPM
white matter: 125 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 3.02
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

actin cytoskeleton
adherens junction
cortical actin cytoskeleton
cytoplasm
dendrite
dendritic spine head
extrinsic component of postsynaptic membrane
filopodium
glutamatergic synapse
growth cone
lamellipodium
neuronal cell body
nucleoplasm
plasma membrane
postsynaptic density
protein phosphatase type 1 complex
ruffle membrane
spine apparatus
cytoplasmic side of dendritic spine plasma membrane
dendritic spine neck

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R9B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R9B as an antibody target. Whether an autoantibody or antibody against PPP1R9B could matter depends on whether native PPP1R9B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R9B is annotated at the cell surface, where native PPP1R9B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label PPP1R9B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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