Seroatlas · Human Serome Atlas

PPP1R2B

Protein phosphatase inhibitor 2 family member B

Also known as: IPP2B_HUMAN, MGC87149, PPP1R2P3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6NXS1
Gene
PPP1R2B
Ensembl
ENSG00000231989
Chromosome
5
Canonical length
205 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to enable protein phosphatase inhibitor activity. Predicted to be involved in intracellular signal transduction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q6NXS1|PPP1R2B
     1  MAASTASHRP IKGILKNKTS TTSSMVASAE QPRRSVDEEL SKKSQKWDEI NILATYHPAD
    61  KGYGLMKIDE PSPPYHSMMG DDEDACRDTE TTEAMAPDIL AKKLAAAEGL EPKYRIQEQE
   121  SSGEEDSDLS PEEREKKRQF EMRRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMLETADG
   181  ESMNTEESNQ GSTPSDQQQN KLRSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R2B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.64
Highest tissue expression
21 nTPM

Expression across tissuesHPA

Tissue

  • testis: 21 nTPM
  • skeletal muscle: 0.1 nTPM
  • adipose tissue: 0 nTPM
  • adrenal gland: 0 nTPM
  • amygdala: 0 nTPM
  • appendix: 0 nTPM

Single-cell type

  • late primary spermatocytes: 516 nCPM
  • late spermatids: 457 nCPM
  • early spermatids: 282 nCPM
  • early primary spermatocytes: 26 nCPM
  • sertoli cells: 3.7 nCPM
  • leydig cells: 1.6 nCPM

Immune cell

  • eosinophil: 0.3 nTPM
  • basophil: 0.1 nTPM
  • MAIT T-cell: 0.1 nTPM
  • memory CD4 T-cell: 0.1 nTPM
  • naive B-cell: 0.1 nTPM
  • naive CD4 T-cell: 0.1 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • medulla oblongata: 0.2 nTPM
  • amygdala: 0.1 nTPM
  • basal ganglia: 0.1 nTPM
  • cerebellum: 0.1 nTPM
  • hippocampal formation: 0.1 nTPM

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R2B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R2B as an antibody target. Whether an autoantibody or antibody against PPP1R2B could matter depends on whether native PPP1R2B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R2B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R2B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/PPP1R2B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...