Seroatlas · Human Serome Atlas

CDCA2

Cell division cycle-associated protein 2

Also known as: CDCA2_HUMAN, PPP1R81, Repo-Man

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q69YH5
Gene: CDCA2
Ensembl: ENSG00000184661
Chromosome: 8
Canonical length: 1023 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a targeting subunit of the cell-cycle associated protein, protein phosphatase 1, with a role in targeting this protein to chromatin during anaphase. These two proteins comprise a phosphatase complex that is involved in nuclear envelope reformation and regulation of the DNA damage response. The encoded protein may also play a role in cancer progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

Canonical amino-acid sequenceUniProt

1023 residues, UniProt reviewed canonical sequence.

>Q69YH5|CDCA2
     1  MDANSKDKPP ETKESAMNNA GNASFILGTG KIVTPQKHAE LPPNPCTPDT FKSPLNFSTV
    61  TVEQLGITPE SFVRNSAGKS SSYLKKCRRR SAVGARGSPE TNHLIRFIAR QQNIKNARKS
   121  PLAQDSPSQG SPALYRNVNT LRERISAFQS AFHSIKENEK MTGCLEFSEA GKESEMTDLT
   181  RKEGLSACQQ SGFPAVLSSK RRRISYQRDS DENLTDAEGK VIGLQIFNID TDRACAVETS
   241  VDLSEISSKL GSTQSGFLVE ESLPLSELTE TSNALKVADC VVGKGSSDAV SPDTFTAEVS
   301  SDAVPDVRSP ATPACRRDLP TPKTFVLRSV LKKPSVKMCL ESLQEHCNNL YDDDGTHPSL
   361  ISNLPNCCKE KEAEDEENFE APAFLNMRKR KRVTFGEDLS PEVFDESLPA NTPLRKGGTP
   421  VCKKDFSGLS SLLLEQSPVP EPLPQPDFDD KGENLENIEP LQVSFAVLSS PNKSSISETL
   481  SGTDTFSSSN NHEKISSPKV GRITRTSNRR NQLVSVVEES VCNLLNTEVQ PCKEKKINRR
   541  KSQETKCTKR ALPKKSQVLK SCRKKKGKGK KSVQKSLYGE RDIASKKPLL SPIPELPEVP
   601  EMTPSIPSIR RLGSGYFSSN GKLEEVKTPK NPVKRKDLLR HDPDLHMHQG YDKYDVSEFC
   661  SYIKSSSSLG NATSDEDPNT NIMNINENKN IPKAKNKSES ENEPKAGTDS PVSCASVTEE
   721  RVASDSPKPA LTLQQGQEFS AGGQNAENLC QFFKISPDLN IKCERKDDFL GAAEGKLQCN
   781  RLMPNSQKDC HCLGDVLIEN TKESKSQSED LGRKPMESSS VVSCRDRKDR RRSMCYSDGR
   841  SLHLEKNGNH TPSSSVGSSV EISLENSELF KDLSDAIEQT FQRRNSETKV RRSTRLQKDL
   901  ENEGLVWISL PLPSTSQKAK RRTICTFDSS GFESMSPIKE TVSSRQKPQM APPVSDPENS
   961  QGPAAGSSDE PGKRRKSFCI STLANTKATS QFKGYRRRSS LNGKGESSLT ALERIEHNGE
  1021  RKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDCA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.7
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

testis: 18 nTPM
thymus: 11 nTPM
tonsil: 6.3 nTPM
bone marrow: 6.1 nTPM
lymph node: 4.9 nTPM
appendix: 2.4 nTPM

Single-cell type

late primary spermatocytes: 109 nCPM
monocyte progenitors: 74 nCPM
erythrocyte progenitors: 64 nCPM
early primary spermatocytes: 54 nCPM
differentiating spermatogonia: 52 nCPM
undifferentiated spermatogonia: 40 nCPM

Immune cell

NK-cell: 0.6 nTPM
T-reg: 0.4 nTPM
memory B-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

thalamus: 0.7 nTPM
pons: 0.5 nTPM
cerebellum: 0.3 nTPM
medulla oblongata: 0.3 nTPM
white matter: 0.3 nTPM
basal ganglia: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.04
gnomAD pLI: 0
gnomAD missense Z: -0.43
DepMap mean gene effect: -0.16
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein phosphatase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDCA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDCA2 as an antibody target. Whether an autoantibody or antibody against CDCA2 could matter depends on whether native CDCA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDCA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDCA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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