Seroatlas · Human Serome Atlas

DYNLT4

Dynein light chain Tctex-type 4

Also known as: DYLT4_HUMAN, TCTEX1D4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5JR98
Gene: DYNLT4
Ensembl: ENSG00000188396
Chromosome: 1
Canonical length: 221 aa
Protein class: Predicted intracellular proteins
Subcellular location: Vesicles

OverviewNCBI Gene

Enables protein phosphatase 1 binding activity. Predicted to be involved in microtubule-based movement. Located in several cellular components, including acrosomal vesicle; cytoskeleton; and sperm flagellum. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

221 residues, UniProt reviewed canonical sequence.

>Q5JR98|DYNLT4
     1  MASRPLPPGR QEEENAKDSG RKPSPVRPRG CLPSIDEARP AGPGPAPASR RGSMLGLAAS
    61  FSRRNSLVGP GAGPGGQRPS LGPVPPLGSR VSFSGLPLAP ARWVAPSYRT EPVPGERWEA
   121  ARAQRALEAA LAAGLHDACY SSDEAARLVR ELCEQVHVRL RELSPPRYKL VCSVVLGPRA
   181  GQGVHVVSRA LWDVARDGLA SVSYTNTSLF AVATVHGLYC E

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against DYNLT4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 23 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 23 nTPM
fallopian tube: 6.5 nTPM
lung: 2.8 nTPM
bone marrow: 2.3 nTPM
epididymis: 2.1 nTPM
adrenal gland: 1.9 nTPM

Single-cell type

epididymal efferent duct ciliated cells: 391 nCPM
fallopian tube ciliated cells: 221 nCPM
respiratory ciliated cells: 217 nCPM
endometrial ciliated cells: 101 nCPM
epididymal principal cells: 28 nCPM
tuft cells: 12 nCPM

Immune cell

neutrophil: 8 nTPM
classical monocyte: 0.6 nTPM
total PBMC: 0.2 nTPM
intermediate monocyte: 0.1 nTPM
memory CD4 T-cell: 0.1 nTPM
basophil: 0 nTPM

Brain region

choroid plexus: 43 nTPM
medulla oblongata: 12 nTPM
thalamus: 10 nTPM
midbrain: 9.6 nTPM
pons: 7.9 nTPM
white matter: 7.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.71
gnomAD pLI: 0.01
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

microtubule-based movement

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of DYNLT4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads DYNLT4 as an antibody target. Whether an autoantibody or antibody against DYNLT4 could matter depends on whether native DYNLT4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

DYNLT4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label DYNLT4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...