Seroatlas · Human Serome Atlas

NOM1

Nucleolar MIF4G domain-containing protein 1

Also known as: C7orf3, NOM1_HUMAN, PPP1R113, SGD1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5C9Z4
Gene: NOM1
Ensembl: ENSG00000146909
Chromosome: 7
Canonical length: 860 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

Proteins that contain MIF4G (middle of eIF4G (MIM 600495)) and/or MA3 domains, such as NOM1, function in protein translation. These domains include binding sites for members of the EIF4A family of ATP-dependent DEAD box RNA helicases (see EIF4A1; MIM 602641) (Simmons et al., 2005 [PubMed 15715967]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

860 residues, UniProt reviewed canonical sequence.

>Q5C9Z4|NOM1
     1  MAASRSAGEA GPGGSQGRVV RMKRRGGRGP RRGPAGGGEK ALKRLKLAVE EFVHATSEGE
    61  APGGCEGRGA PVSFRPGGRK SRKELRKEKR HLRKARRLQR TAGPEQGPGL GGRSGAEEAS
   121  GHRQDTEERA RPAPSRDPSP PRKPRPSRVK AKATAATAKT RPSAAATAAA RKRALLAANE
   181  EEDREIRKLE RCLGLNKRKK KDGSSSVPLS FARDGLDYIL GALESGKNSG LYDSSGEEEE
   241  DAGQTLPESD LESDSQDESE EEEEGDVEKE KKAQEAEAQS EDDDEDTEEE QGEEKEKGAQ
   301  EKRRGKRVRF AEDEEKSENS SEDGDITDKS LCGSGEKYIP PHVRQAEETV DFKKKEELER
   361  LKKHVKGLLN RLSEPNMASI SGQLEELYMA HSRKDMNDTL TSALMGACVT ASAMPSRLMM
   421  EHVLLVSILH HTVGIEVGAH FLEAVVRKFD AIYKYGSEGK ECDNLFTVIA HLYNFHVVQS
   481  LLIFDILKKL IGTFTEKDIE LILLMLKNVG FSLRKDDALS LKELITEAQT KASGAGSEFQ
   541  DQTRIRFMLE TMLALKNNDM RKIPGYDPEP VEKLRKLQRA LVRNAGSGSE TQLRVSWDSV
   601  LSAEQTGRWW IVGSAWSGAP MIDNSHHTHL QKQLVGTVSS KILELARKQR MNTDIRRNIF
   661  CTIMTSEDFL DAFEKLLKLG LKDQQEREII HVLMDCCLQE KTYNPFYAFL ASKFCEYERR
   721  FQMTFQFSIW DKFRDLENLP ATNFSNLVHL VAHLLKTKSL SLSILKVVEF SELDKPRVRF
   781  LRKVLSILLM ETEVEDLSLI FTRVSDNPKL GVLREGLKLF ISHFLLKNAQ AHRSADEANV
   841  LREKADLATK CLQGKASLRM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NOM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 7 nTPM
bone marrow: 6.4 nTPM
skin: 5.8 nTPM
pancreas: 5.6 nTPM
lymph node: 5.3 nTPM
ovary: 5 nTPM

Single-cell type

erythrocyte progenitors: 68 nCPM
basal keratinocytes: 51 nCPM
differentiating spermatogonia: 49 nCPM
suprabasal keratinocytes: 47 nCPM
megakaryocyte progenitors: 42 nCPM
esophageal basal cells: 41 nCPM

Immune cell

naive B-cell: 1.8 nTPM
memory B-cell: 1.3 nTPM
naive CD4 T-cell: 0.9 nTPM
basophil: 0.8 nTPM
classical monocyte: 0.8 nTPM
memory CD8 T-cell: 0.8 nTPM

Brain region

cerebral cortex: 9.8 nTPM
pons: 9.7 nTPM
medulla oblongata: 9.4 nTPM
white matter: 9.3 nTPM
thalamus: 8.8 nTPM
choroid plexus: 8.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.9
gnomAD pLI: 0
gnomAD missense Z: -0.97
DepMap mean gene effect: -0.73
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

nucleolus

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NOM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NOM1 as an antibody target. Whether an autoantibody or antibody against NOM1 could matter depends on whether native NOM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NOM1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NOM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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