Seroatlas · Human Serome Atlas

LMTK2

Serine/threonine-protein kinase LMTK2

Also known as: AATYK2, BREK, cprk, KIAA1079, KPI-2, KPI2, LMR2, LMTK2_HUMAN, PPP1R100

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8IWU2
Gene: LMTK2
Ensembl: ENSG00000164715
Chromosome: 7
Canonical length: 1503 aa
Protein class: Enzymes, Predicted membrane proteins
Subcellular location: Nuclear speckles,Plasma membrane,Centriolar satellite,Cytosol

OverviewNCBI Gene

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (cdk5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

Canonical amino-acid sequenceUniProt

1503 residues, UniProt reviewed canonical sequence.

>Q8IWU2|LMTK2
     1  MPGPPALRRR LLLLLLVLLI AGSAGAAPLP QTGAGEAPPA AEVSSSFVIL CVCSLIILIV
    61  LIANCVSCCK DPEIDFKEFE DNFDDEIDFT PPAEDTPSVQ SPAEVFTLSV PNISLPAPSQ
   121  FQPSVEGLKS QVARHSLNYI QEIGNGWFGK VLLGEIYTGT SVARVIVKEL KASANPKEQD
   181  TFLKNGEPYY ILQHPNILQC VGQCVEAIPY LLVFEFCDLG DLKAYLRSEQ EHMRGDSQTM
   241  LLQRMACEVA AGLAAMHKLH FLHSDLALRN CFLTSDLNVK VGDYGIGFSR YKEDYIETDD
   301  KKVFPLRWTA PELVTSFQDR LLTADQTKYS NIWSLGVTLW ELFDNAAQPY SNLSNLDVLN
   361  QVIRERDTKL PKPQLEQPYS DRWYEVLQFC WLSPEKRPAA EDVHRLLTYL RLQSQRDSEV
   421  DFEQQWNALK PNTNSRDSSN NAAFPILDHF ARDRLGREME EVLTVTETSQ GLSFEYVWEA
   481  AKHDHFDERS RGHLDEGLSY TSIFYPVEVF ESSLSDPGPG KQDDSGQDVP LRVPGVVPVF
   541  DAHNLSVGSD YYIQLEEKSG SNLELDYPPA LLTTDMDNPE RTGPELSQLT ALRSVELEES
   601  STDEDFFQSS TDPKDSSLPG DLHVTSGPES PFNNIFNDVD KSEDLPSHQK IFDLMELNGV
   661  QADFKPATLS SSLDNPKESV ITGHFEKEKP RKIFDSEPLC LSDNLMHQDN FDPLNVQELS
   721  ENFLFLQEKN LLKGSLSSKE HINDLQTELK NAGFTEAMLE TSCRNSLDTE LQFAENKPGL
   781  SLLQENVSTK GDDTDVMLTG DTLSTSLQSS PEVQVPPTSF ETEETPRRVP PDSLPTQGET
   841  QPTCLDVIVP EDCLHQDISP DAVTVPVEIL STDARTHSLD NRSQDSPGES EETLRLTESD
   901  SVLADDILAS RVSVGSSLPE LGQELHNKPF SEDHHSHRRL EKNLEAVETL NQLNSKDAAK
   961  EAGLVSALSS DSTSQDSLLE DSLSAPFPAS EPSLETPDSL ESVDVHEALL DSLGSHTPQK
  1021  LVPPDKPADS GYETENLESP EWTLHPAPEG TADSEPATTG DGGHSGLPPN PVIVISDAGD
  1081  GHRGTEVTPE TFTAGSQGSY RDSAYFSDND SEPEKRSEEV PGTSPSALVL VQEQPLPEPV
  1141  LPEQSPAAQD SCLEARKSQP DESCLSALHN SSDLELRATP EPAQTGVPQQ VHPTEDEASS
  1201  PWSVLNAELS SGDDFETQDD RPCTLASTGT NTNELLAYTN SALDKSLSSH SEGPKLKEPD
  1261  IEGKYLGKLG VSGMLDLSED GMDADEEDEN SDDSDEDLRA FNLHSLSSES EDETEHPVPI
  1321  ILSNEDGRHL RSLLKPTAAN APDPLPEDWK KEKKAVTFFD DVTVYLFDQE TPTKELGPCG
  1381  GEACGPDLSG PAPASGSPYL SRCINSESST DEEGGGFEWD DDFSPDPFMS KTTSNLLSSK
  1441  PSLQTSKYFS PPPPARSTEQ SWPHSAPYSR FSISPANIAS FSLTHLTDSD IEQGGSSEDG
  1501  EKD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against LMTK2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 2
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 16 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 16 nTPM
pancreas: 14 nTPM
bone marrow: 13 nTPM
heart muscle: 12 nTPM
skeletal muscle: 10 nTPM
parathyroid gland: 10 nTPM

Single-cell type

urothelial cells: 553 nCPM
neutrophils: 488 nCPM
enterocytes: 331 nCPM
endometrial glandular cells: 290 nCPM
esophageal apical cells: 240 nCPM
colonocytes: 232 nCPM

Immune cell

neutrophil: 1.4 nTPM
basophil: 0.4 nTPM
naive CD8 T-cell: 0.4 nTPM
naive CD4 T-cell: 0.3 nTPM
non-classical monocyte: 0.3 nTPM
gdT-cell: 0.2 nTPM

Brain region

cerebral cortex: 105 nTPM
white matter: 70 nTPM
basal ganglia: 59 nTPM
hippocampal formation: 56 nTPM
pons: 52 nTPM
amygdala: 49 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 1
gnomAD missense Z: 1.29
DepMap mean gene effect: -0.05
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of LMTK2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads LMTK2 as an antibody target. Whether an autoantibody or antibody against LMTK2 could matter depends on whether native LMTK2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

LMTK2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label LMTK2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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