Seroatlas · Human Serome Atlas

PPP1R42

Protein phosphatase 1 regulatory subunit 42

Also known as: dtr, LRRC67, PPR42_HUMAN, TLLR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z4L9
Gene: PPP1R42
Ensembl: ENSG00000178125
Chromosome: 8
Canonical length: 309 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene can interact with gamma-tubulin and PP1 phosphatase, a regulator of centrosome separation. The encoded protein is a positive regulator of PP1 phosphatase and thus plays a role in the control of centrosome integrity. [provided by RefSeq, Feb 2017]

Canonical amino-acid sequenceUniProt

309 residues, UniProt reviewed canonical sequence.

>Q7Z4L9|PPP1R42
     1  MVRLTLDLIA RNSNLKPRKE ETISQCLKKI THINFSDKNI DAIEDLSLCK NLSVLYLYDN
    61  CISQITNLNY ATNLTHLYLQ NNCISCIENL RSLKKLEKLY LGGNYIAVIE GLEGLGELRE
   121  LHVENQRLPL GEKLLFDPRT LHSLAKSLCI LNISNNNIDD ITDLELLENL NQLIAVDNQL
   181  LHVKDLEFLL NKLMKLWKID LNGNPVCLKP KYRDRLILVS KSLEFLDGKE IKNIERQFLM
   241  NWKASKDAKK ISKKRSSKNE DASNSLISNF KTMHHIVPVY YPQVGKPKLA FFSEIQRYPV
   301  NANASPESS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R42 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 8.5 nTPM

Expression across tissuesHPA

Tissue

testis: 8.5 nTPM
fallopian tube: 5.1 nTPM
choroid plexus: 1.1 nTPM
retina: 0.6 nTPM
hypothalamus: 0.3 nTPM
lung: 0.3 nTPM

Single-cell type

ependymal cells: 647 nCPM
respiratory ciliated cells: 323 nCPM
late primary spermatocytes: 283 nCPM
fallopian tube ciliated cells: 243 nCPM
choroid plexus epithelial cells: 196 nCPM
epididymal efferent duct ciliated cells: 162 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

medulla oblongata: 3.1 nTPM
choroid plexus: 3 nTPM
midbrain: 2.6 nTPM
spinal cord: 1.9 nTPM
white matter: 1.3 nTPM
hypothalamus: 1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.49
gnomAD pLI: 0
gnomAD missense Z: 1.01
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R42 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R42 as an antibody target. Whether an autoantibody or antibody against PPP1R42 could matter depends on whether native PPP1R42 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R42 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R42 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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