PPP1R3C

Protein identityUniProt · HPA

UniProt accession

Q9UQK1

Gene

PPP1R3C

Ensembl

ENSG00000119938

Chromosome

10

Canonical length

317 aa

Protein class

Metabolic proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene encodes a carbohydrate binding protein that is a subunit of the protein phosphatase 1 (PP1) complex. PP1 catalyzes reversible protein phosphorylation, which is important in a wide range of cellular activities. The encoded protein affects glycogen biosynthesis by activating glycogen synthase and limiting glycogen breakdown by reducing glycogen phosphorylase activity. DNA hypermethylation of this gene has been found in colorectal cancer patients. The encoded protein also interacts with the laforin protein, which is a protein tyrosine phosphatase implicated in Lafora disease. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

317 residues, UniProt reviewed canonical sequence.

>Q9UQK1|PPP1R3C
     1  MSCTRMIQVL DPRPLTSSVM PVDVAMRLCL AHSPPVKSFL GPYDEFQRRH FVNKLKPLKS
    61  CLNIKHKAKS QNDWKCSHNQ AKKRVVFADS KGLSLTAIHV FSDLPEEPAW DLQFDLLDLN
   121  DISSALKHHE EKNLILDFPQ PSTDYLSFRS HFQKNFVCLE NCSLQERTVT GTVKVKNVSF
   181  EKKVQIRITF DSWKNYTDVD CVYMKNVYGG TDSDTFSFAI DLPPVIPTEQ KIEFCISYHA
   241  NGQVFWDNND GQNYRIVHVQ WKPDGVQTQM APQDCAFHQT SPKTELESTI FGSPRLASGL
   301  FPEWQSWGRM ENLASYR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.53

Highest tissue expression

851 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.96

gnomAD pLI

0

gnomAD missense Z

0.11

DepMap mean gene effect

-0.02

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• glycogen biosynthetic process
• glycogen metabolic process
• regulation of glycogen biosynthetic process

Molecular functions

• glycogen binding
• protein phosphatase 1 binding
• protein phosphatase binding
• protein serine/threonine phosphatase activity
• protein-macromolecule adaptor activity

Cellular components

• cytosol
• protein phosphatase type 1 complex

Protein domainsUniProt · Pfam · InterPro

• CBM21 (carbohydrate binding type-21) domain
• Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
• CBM21 domain superfamily
• Protein phosphatase 1 regulatory subunit 3
• Carbohydrate/starch-binding module (family 21)
• Protein phosphatase 1 regulatory subunit 3C

KeywordsUniProt

• Carbohydrate metabolism
• Glycogen metabolism
• Ubl conjugation

InteractionsUniProt · HPA

Protein binding partners of PPP1R3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EPM2A
• GYS1
• PPP1CA
• PPP1CB
• PPP1CC