Seroatlas · Human Serome Atlas

PPP1R3B

Protein phosphatase 1 regulatory subunit 3B

Also known as: FLJ14005, GL, PPP1R4, PPR3B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q86XI6
Gene: PPP1R3B
Ensembl: ENSG00000173281
Chromosome: 8
Canonical length: 285 aa
Protein class: Metabolic proteins, Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes the catalytic subunit of the serine/theonine phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

Canonical amino-acid sequenceUniProt

285 residues, UniProt reviewed canonical sequence.

>Q86XI6|PPP1R3B
     1  MMAVDIEYRY NCMAPSLRQE RFAFKISPKP SKPLRPCIQL SSKNEASGMV APAVQEKKVK
    61  KRVSFADNQG LALTMVKVFS EFDDPLDMPF NITELLDNIV SLTTAESESF VLDFSQPSAD
   121  YLDFRNRLQA DHVCLENCVL KDKAIAGTVK VQNLAFEKTV KIRMTFDTWK SYTDFPCQYV
   181  KDTYAGSDRD TFSFDISLPE KIQSYERMEF AVYYECNGQT YWDSNRGKNY RIIRAELKST
   241  QGMTKPHSGP DLGISFDQFG SPRCSYGLFP EWPSYLGYEK LGPYY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R3B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 135 nTPM

Expression across tissuesHPA

Tissue

liver: 135 nTPM
skeletal muscle: 89 nTPM
parathyroid gland: 47 nTPM
blood vessel: 41 nTPM
heart muscle: 28 nTPM
urinary bladder: 28 nTPM

Single-cell type

loop of henle epithelial cells: 22 nCPM
papillary tip epithelial cells: 18 nCPM
renal collecting duct principal cells: 17 nCPM
podocytes: 17 nCPM
proximal tubule cells: 13 nCPM
renal connecting tubule cells: 12 nCPM

Immune cell

basophil: 53 nTPM
neutrophil: 50 nTPM
eosinophil: 16 nTPM
naive CD4 T-cell: 2.7 nTPM
NK-cell: 2.2 nTPM
gdT-cell: 2.1 nTPM

Brain region

choroid plexus: 12 nTPM
medulla oblongata: 9.7 nTPM
white matter: 8.7 nTPM
thalamus: 8.2 nTPM
cerebral cortex: 7.7 nTPM
pons: 6.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PPP1R3B.

Disease | ImmuneIEDB

Conditions an epitope on PPP1R3B was assayed in.

melanoma T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.99
gnomAD pLI: 0.07
gnomAD missense Z: -1.11
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

glycogen metabolic process
positive regulation of glycogen biosynthetic process
regulation of glycogen biosynthetic process
negative regulation of glycogen catabolic process

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

CBM21 (carbohydrate binding type-21) domain
Protein phosphatase 1 regulatory subunit 3B/C/D, metazoa
CBM21 domain superfamily
Protein phosphatase 1 regulatory subunit 3
Carbohydrate/starch-binding module (family 21)
Protein phosphatase 1 regulatory subunit 3B

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R3B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R3B as an antibody target. Whether an autoantibody or antibody against PPP1R3B could matter depends on whether native PPP1R3B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R3B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R3B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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