Seroatlas · Human Serome Atlas

PPP1R7

Protein phosphatase 1 regulatory subunit 7

Also known as: PP1R7_HUMAN, sds22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q15435
Gene: PPP1R7
Ensembl: ENSG00000115685
Chromosome: 2
Canonical length: 360 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoli

OverviewNCBI Gene

This gene encodes a protein subunit that regulates the activity of the serine/threonine phosphatase, protein phosphatase-1. The encoded protein is required for completion of the mitotic cycle and for targeting protein phosphatase-1 to mitotic kinetochores. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q15435|PPP1R7
     1  MAAERGAGQQ QSQEMMEVDR RVESEESGDE EGKKHSSGIV ADLSEQSLKD GEERGEEDPE
    61  EEHELPVDME TINLDRDAED VDLNHYRIGK IEGFEVLKKV KTLCLRQNLI KCIENLEELQ
   121  SLRELDLYDN QIKKIENLEA LTELEILDIS FNLLRNIEGV DKLTRLKKLF LVNNKISKIE
   181  NLSNLHQLQM LELGSNRIRA IENIDTLTNL ESLFLGKNKI TKLQNLDALT NLTVLSMQSN
   241  RLTKIEGLQN LVNLRELYLS HNGIEVIEGL ENNNKLTMLD IASNRIKKIE NISHLTELQE
   301  FWMNDNLLES WSDLDELKGA RSLETVYLER NPLQKDPQYR RKVMLALPSV RQIDATFVRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 174 nTPM

Expression across tissuesHPA

Tissue

basal ganglia: 174 nTPM
testis: 148 nTPM
cerebral cortex: 103 nTPM
skeletal muscle: 99 nTPM
heart muscle: 94 nTPM
amygdala: 93 nTPM

Single-cell type

late spermatids: 2,387 nCPM
early spermatids: 981 nCPM
late primary spermatocytes: 860 nCPM
esophageal apical cells: 445 nCPM
oocytes: 327 nCPM
esophageal suprabasal cells: 256 nCPM

Immune cell

T-reg: 122 nTPM
eosinophil: 109 nTPM
basophil: 108 nTPM
non-classical monocyte: 97 nTPM
total PBMC: 90 nTPM
intermediate monocyte: 88 nTPM

Brain region

basal ganglia: 100 nTPM
cerebral cortex: 71 nTPM
hippocampal formation: 61 nTPM
white matter: 58 nTPM
amygdala: 49 nTPM
hypothalamus: 48 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.24
gnomAD pLI: 0.99
gnomAD missense Z: 1.86
DepMap mean gene effect: -0.82
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R7 as an antibody target. Whether an autoantibody or antibody against PPP1R7 could matter depends on whether native PPP1R7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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