Seroatlas · Human Serome Atlas

PPP1R2

Protein phosphatase inhibitor 2

Also known as: IPP2, IPP2_HUMAN, PPP1R2A

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P41236
Gene: PPP1R2
Ensembl: ENSG00000184203
Chromosome: 3
Canonical length: 205 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>P41236|PPP1R2
     1  MAASTASHRP IKGILKNKTS TTSSMVASAE QPRGNVDEEL SKKSQKWDEM NILATYHPAD
    61  KDYGLMKIDE PSTPYHSMMG DDEDACSDTE ATEAMAPDIL ARKLAAAEGL EPKYRIQEQE
   121  SSGEEDSDLS PEEREKKRQF EMKRKLHYNE GLNIKLARQL ISKDLHDDDE DEEMLETADG
   181  ESMNTEESNQ GSTPSDQQQN KLRSS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PPP1R2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 80 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 80 nTPM
bone marrow: 64 nTPM
tongue: 53 nTPM
lymph node: 27 nTPM
testis: 27 nTPM
thymus: 26 nTPM

Single-cell type

esophageal apical cells: 505 nCPM
late primary spermatocytes: 466 nCPM
lymphatic endothelial cells: 328 nCPM
t-cells: 309 nCPM
neutrophils: 299 nCPM
early spermatids: 249 nCPM

Immune cell

eosinophil: 258 nTPM
naive CD4 T-cell: 179 nTPM
T-reg: 169 nTPM
neutrophil: 153 nTPM
memory CD4 T-cell: 150 nTPM
total PBMC: 129 nTPM

Brain region

hypothalamus: 45 nTPM
pons: 37 nTPM
choroid plexus: 35 nTPM
hippocampal formation: 35 nTPM
cerebral cortex: 35 nTPM
basal ganglia: 34 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.75
gnomAD pLI: 0.07
gnomAD missense Z: 0.68
DepMap mean gene effect: -0.57
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of PPP1R2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads PPP1R2 as an antibody target. Whether an autoantibody or antibody against PPP1R2 could matter depends on whether native PPP1R2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

PPP1R2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label PPP1R2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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