CSRNP2

Protein identityUniProt · HPA

UniProt accession

Q9H175

Gene

CSRNP2

Ensembl

ENSG00000110925

Chromosome

12

Canonical length

543 aa

Protein class

Predicted intracellular proteins, Transcription factors

Subcellular location

Nuclear speckles

OverviewNCBI Gene

The protein encoded by this gene belongs to the CSRNP family of nuclear proteins that share conserved regions, including cysteine- and serine- rich regions, a basic domain, a transcriptional activation domain, and bind the sequence 'AGAGTG', thus have the hallmark of transcription factors. Studies in mice suggest that these genes may have redundant functions. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

543 residues, UniProt reviewed canonical sequence.

>Q9H175|CSRNP2
     1  MDAFTGSGLK RKFDDVDVGS SVSNSDDEIS SSDSADSCDS LNPPTTASFT PTSILKRQKQ
    61  LRRKNVRFDQ VTVYYFARRQ GFTSVPSQGG SSLGMAQRHN SVRSYTLCEF AQEQEVNHRE
   121  ILREHLKEEK LHAKKMKLTK NGTVESVEAD GLTLDDVSDE DIDVENVEVD DYFFLQPLPT
   181  KRRRALLRAS GVHRIDAEEK QELRAIRLSR EECGCDCRLY CDPEACACSQ AGIKCQVDRM
   241  SFPCGCSRDG CGNMAGRIEF NPIRVRTHYL HTIMKLELES KRQVSRPAAP DEEPSPTASC
   301  SLTGAQGSET QDFQEFIAEN ETAVMHLQSA EELERLKAEE DSSGSSASLD SSIESLGVCI
   361  LEEPLAVPEE LCPGLTAPIL IQAQLPPGSS VLCFTENSDH PTASTVNSPS YLNSGPLVYY
   421  QVEQRPVLGV KGEPGTEEGS ASFPKEKDLN VFSLPVTSLV ACSSTDPAAL CKSEVGKTPT
   481  LEALLPEDCN PEEPENEDFH PSWSPSSLPF RTDNEEGCGM VKTSQQNEDR PPEDSSLELP
   541  LAV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CSRNP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.57

Highest tissue expression

25 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.33

gnomAD pLI

0.96

gnomAD missense Z

2.17

DepMap mean gene effect

-0.06

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• apoptotic process
• positive regulation of transcription by RNA polymerase II
• regulation of transcription by RNA polymerase II

Molecular functions

• DNA-binding transcription activator activity, RNA polymerase II-specific
• DNA-binding transcription factor activity
• DNA-binding transcription factor activity, RNA polymerase II-specific
• phosphatase binding
• sequence-specific DNA binding

Cellular components

• chromatin
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Cysteine/serine-rich nuclear protein family
• Cysteine/serine-rich nuclear protein, N-terminal domain
• Cysteine/serine-rich nuclear protein N-terminus

KeywordsUniProt

• Acetylation
• Activator
• Apoptosis
• DNA-binding
• Nucleus
• Transcription
• Transcription regulation

InteractionsUniProt · HPA

Protein binding partners of CSRNP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• PPP1CA
• PPP1CC