Seroatlas · Human Serome Atlas

MAPK14

Mitogen-activated protein kinase 14

Also known as: CSBP1, CSBP2, CSPB1, MK14_HUMAN, Mxi2, p38, PRKM14, PRKM15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q16539
Gene
MAPK14
Ensembl
ENSG00000112062
Chromosome
6
Canonical length
360 aa
Protein class
Cancer-related genes, Enzymes, Predicted intracellular proteins
Subcellular location
Nuclear speckles,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q16539|MAPK14
     1  MSQERPTFYR QELNKTIWEV PERYQNLSPV GSGAYGSVCA AFDTKTGLRV AVKKLSRPFQ
    61  SIIHAKRTYR ELRLLKHMKH ENVIGLLDVF TPARSLEEFN DVYLVTHLMG ADLNNIVKCQ
   121  KLTDDHVQFL IYQILRGLKY IHSADIIHRD LKPSNLAVNE DCELKILDFG LARHTDDEMT
   181  GYVATRWYRA PEIMLNWMHY NQTVDIWSVG CIMAELLTGR TLFPGTDHID QLKLILRLVG
   241  TPGAELLKKI SSESARNYIQ SLTQMPKMNF ANVFIGANPL AVDLLEKMLV LDSDKRITAA
   301  QALAHAYFAQ YHDPDDEPVA DPYDQSFESR DLLIDEWKSL TYDEVISFVP PPLDQEEMES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against MAPK14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.27
Highest tissue expression
86 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 86 nTPM
  • placenta: 43 nTPM
  • spleen: 40 nTPM
  • liver: 40 nTPM
  • smooth muscle: 37 nTPM
  • thymus: 37 nTPM

Single-cell type

  • neutrophils: 2,780 nCPM
  • neutrophil progenitors: 1,492 nCPM
  • monocyte progenitors: 731 nCPM
  • hematopoietic stem cells: 300 nCPM
  • megakaryocyte-erythroid progenitors: 281 nCPM
  • megakaryocyte progenitors: 233 nCPM

Immune cell

  • basophil: 78 nTPM
  • neutrophil: 26 nTPM
  • non-classical monocyte: 11 nTPM
  • classical monocyte: 11 nTPM
  • myeloid DC: 8.4 nTPM
  • intermediate monocyte: 7.4 nTPM

Brain region

  • choroid plexus: 39 nTPM
  • cerebellum: 39 nTPM
  • hypothalamus: 37 nTPM
  • cerebral cortex: 34 nTPM
  • basal ganglia: 33 nTPM
  • thalamus: 31 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.37
gnomAD missense Z
3.31
DepMap mean gene effect
-0.2
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of MAPK14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads MAPK14 as an antibody target. Whether an autoantibody or antibody against MAPK14 could matter depends on whether native MAPK14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

MAPK14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label MAPK14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/MAPK14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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