Seroatlas · Human Serome Atlas

TAB1

TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

Also known as: MAP3K7IP1, TAB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15750
Gene
TAB1
Ensembl
ENSG00000100324
Chromosome
22
Canonical length
504 aa
Protein class
Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

504 residues, UniProt reviewed canonical sequence.

>Q15750|TAB1
     1  MAAQRRSLLQ SEQQPSWTDD LPLCHLSGVG SASNRSYSAD GKGTESHPPE DSWLKFRSEN
    61  NCFLYGVFNG YDGNRVTNFV AQRLSAELLL GQLNAEHAEA DVRRVLLQAF DVVERSFLES
   121  IDDALAEKAS LQSQLPEGVP QHQLPPQYQK ILERLKTLER EISGGAMAVV AVLLNNKLYV
   181  ANVGTNRALL CKSTVDGLQV TQLNVDHTTE NEDELFRLSQ LGLDAGKIKQ VGIICGQEST
   241  RRIGDYKVKY GYTDIDLLSA AKSKPIIAEP EIHGAQPLDG VTGFLVLMSE GLYKALEAAH
   301  GPGQANQEIA AMIDTEFAKQ TSLDAVAQAV VDRVKRIHSD TFASGGERAR FCPRHEDMTL
   361  LVRNFGYPLG EMSQPTPSPA PAAGGRVYPV SVPYSSAQST SKTSVTLSLV MPSQGQMVNG
   421  AHSASTLDEA TPTLTNQSPT LTLQSTNTHT QSSSSSSDGG LFRSRPAHSL PPGEDGRVEP
   481  YVDFAEFYRL WSVDHGEQSV VTAP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
23 nTPM

Expression across tissuesHPA

Tissue

  • cerebellum: 23 nTPM
  • ovary: 20 nTPM
  • skeletal muscle: 19 nTPM
  • cervix: 19 nTPM
  • urinary bladder: 18 nTPM
  • colon: 18 nTPM

Single-cell type

  • retinal bipolar cells: 126 nCPM
  • adrenal medulla cells: 75 nCPM
  • myonuclei: 60 nCPM
  • retinal ganglion cells: 58 nCPM
  • retinal horizontal cells: 52 nCPM
  • oligodendrocytes: 42 nCPM

Immune cell

  • classical monocyte: 5.6 nTPM
  • myeloid DC: 5 nTPM
  • non-classical monocyte: 4.6 nTPM
  • gdT-cell: 4.3 nTPM
  • intermediate monocyte: 4.3 nTPM
  • total PBMC: 4.3 nTPM

Brain region

  • basal ganglia: 37 nTPM
  • white matter: 35 nTPM
  • midbrain: 34 nTPM
  • medulla oblongata: 33 nTPM
  • thalamus: 32 nTPM
  • cerebral cortex: 32 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.93
gnomAD pLI
0
gnomAD missense Z
1.75
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAB1 as an antibody target. Whether an autoantibody or antibody against TAB1 could matter depends on whether native TAB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label TAB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/TAB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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