Seroatlas · Human Serome Atlas

RPS6KA5

Ribosomal protein S6 kinase alpha-5

Also known as: KS6A5_HUMAN, MSK1, RLPK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O75582
Gene
RPS6KA5
Ensembl
ENSG00000100784
Chromosome
14
Canonical length
802 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Nucleoplasm

OverviewNCBI Gene

Enables ATP binding activity and protein kinase activity. Involved in several processes, including interleukin-1-mediated signaling pathway; protein modification process; and regulation of DNA-templated transcription. Located in cytoplasm and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

802 residues, UniProt reviewed canonical sequence.

>O75582|RPS6KA5
     1  MEEEGGSSGG AAGTSADGGD GGEQLLTVKH ELRTANLTGH AEKVGIENFE LLKVLGTGAY
    61  GKVFLVRKIS GHDTGKLYAM KVLKKATIVQ KAKTTEHTRT ERQVLEHIRQ SPFLVTLHYA
   121  FQTETKLHLI LDYINGGELF THLSQRERFT EHEVQIYVGE IVLALEHLHK LGIIYRDIKL
   181  ENILLDSNGH VVLTDFGLSK EFVADETERA YSFCGTIEYM APDIVRGGDS GHDKAVDWWS
   241  LGVLMYELLT GASPFTVDGE KNSQAEISRR ILKSEPPYPQ EMSALAKDLI QRLLMKDPKK
   301  RLGCGPRDAD EIKEHLFFQK INWDDLAAKK VPAPFKPVIR DELDVSNFAE EFTEMDPTYS
   361  PAALPQSSEK LFQGYSFVAP SILFKRNAAV IDPLQFHMGV ERPGVTNVAR SAMMKDSPFY
   421  QHYDLDLKDK PLGEGSFSIC RKCVHKKSNQ AFAVKIISKR MEANTQKEIT ALKLCEGHPN
   481  IVKLHEVFHD QLHTFLVMEL LNGGELFERI KKKKHFSETE ASYIMRKLVS AVSHMHDVGV
   541  VHRDLKPENL LFTDENDNLE IKIIDFGFAR LKPPDNQPLK TPCFTLHYAA PELLNQNGYD
   601  ESCDLWSLGV ILYTMLSGQV PFQSHDRSLT CTSAVEIMKK IKKGDFSFEG EAWKNVSQEA
   661  KDLIQGLLTV DPNKRLKMSG LRYNEWLQDG SQLSSNPLMT PDILGSSGAA VHTCVKATFH
   721  AFNKYKREGF CLQNVDKAPL AKRRKMKKTS TSTETRSSSS ESSHSSSSHS HGKTTPTKTL
   781  QPSNPADSNN PETLFQFSDS VA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against RPS6KA5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
9.3 nTPM

Expression across tissuesHPA

Tissue

  • tongue: 9.3 nTPM
  • breast: 7 nTPM
  • cerebellum: 5.5 nTPM
  • esophagus: 4.9 nTPM
  • skeletal muscle: 4.9 nTPM
  • rectum: 4.8 nTPM

Single-cell type

  • endometrial glandular cells: 1,406 nCPM
  • mast cells: 638 nCPM
  • syncytiotrophoblasts: 633 nCPM
  • endometrial ciliated cells: 590 nCPM
  • bergmann glia: 463 nCPM
  • ependymal cells: 456 nCPM

Immune cell

  • neutrophil: 20 nTPM
  • basophil: 17 nTPM
  • NK-cell: 10 nTPM
  • eosinophil: 9 nTPM
  • T-reg: 7.9 nTPM
  • MAIT T-cell: 6.1 nTPM

Brain region

  • cerebellum: 41 nTPM
  • basal ganglia: 27 nTPM
  • white matter: 27 nTPM
  • thalamus: 20 nTPM
  • medulla oblongata: 19 nTPM
  • midbrain: 19 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.24
gnomAD pLI
1
gnomAD missense Z
2.17
DepMap mean gene effect
0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of RPS6KA5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads RPS6KA5 as an antibody target. Whether an autoantibody or antibody against RPS6KA5 could matter depends on whether native RPS6KA5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

RPS6KA5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label RPS6KA5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/RPS6KA5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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