Seroatlas · Human Serome Atlas

ZFP36L1

mRNA decay activator protein ZFP36L1

Also known as: Berg36, BRF1, cMG1, ERF1, RNF162B, TIS11B, TISB_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q07352
Gene: ZFP36L1
Ensembl: ENSG00000185650
Chromosome: 14
Canonical length: 338 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted intracellular proteins

OverviewNCBI Gene

This gene is a member of the TIS11 family of early response genes, which are induced by various agonists such as the phorbol ester TPA and the polypeptide mitogen EGF. This gene is well conserved across species and has a promoter that contains motifs seen in other early-response genes. The encoded protein contains a distinguishing putative zinc finger domain with a repeating cys-his motif. This putative nuclear transcription factor most likely functions in regulating the response to growth factors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

338 residues, UniProt reviewed canonical sequence.

>Q07352|ZFP36L1
     1  MTTTLVSATI FDLSEVLCKG NKMLNYSAPS AGGCLLDRKA VGTPAGGGFP RRHSVTLPSS
    61  KFHQNQLLSS LKGEPAPALS SRDSRFRDRS FSEGGERLLP TQKQPGGGQV NSSRYKTELC
   121  RPFEENGACK YGDKCQFAHG IHELRSLTRH PKYKTELCRT FHTIGFCPYG PRCHFIHNAE
   181  ERRALAGARD LSADRPRLQH SFSFAGFPSA AATAAATGLL DSPTSITPPP ILSADDLLGS
   241  PTLPDGTNNP FAFSSQELAS LFAPSMGLPG GGSPTTFLFR PMSESPHMFD SPPSPQDSLS
   301  DQEGYLSSSS SSHSGSDSPT LDNSRRLPIF SRLSISDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ZFP36L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.66
Highest tissue expression: 479 nTPM

Expression across tissuesHPA

Tissue

skin: 479 nTPM
vagina: 433 nTPM
ovary: 423 nTPM
cervix: 416 nTPM
blood vessel: 375 nTPM
endometrium: 365 nTPM

Single-cell type

ocular epithelial cells: 2,411 nCPM
prostatic club cells: 2,355 nCPM
suprabasal keratinocytes: 2,238 nCPM
epididymal efferent duct absorptive cells: 1,950 nCPM
epididymal basal cells: 1,662 nCPM
decidual stromal cells: 1,499 nCPM

Immune cell

neutrophil: 2,922 nTPM
naive B-cell: 463 nTPM
memory B-cell: 267 nTPM
total PBMC: 258 nTPM
intermediate monocyte: 245 nTPM
classical monocyte: 242 nTPM

Brain region

medulla oblongata: 355 nTPM
midbrain: 324 nTPM
hypothalamus: 316 nTPM
spinal cord: 287 nTPM
white matter: 281 nTPM
thalamus: 239 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about ZFP36L1.

Disease | ImmuneIEDB

Conditions an epitope on ZFP36L1 was assayed in.

glioblastoma T cell
type 1 diabetes mellitus T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.6
gnomAD pLI: 0.67
gnomAD missense Z: 2.56
DepMap mean gene effect: -0.25
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ZFP36L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ZFP36L1 as an antibody target. Whether an autoantibody or antibody against ZFP36L1 could matter depends on whether native ZFP36L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ZFP36L1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ZFP36L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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