Seroatlas · Human Serome Atlas

YY1AP1

YY1-associated protein 1

Also known as: HCCA2, YAP, YY1AP, YYAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H869
Gene: YY1AP1
Ensembl: ENSG00000163374
Chromosome: 1
Canonical length: 796 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoli fibrillar center

OverviewNCBI Gene

Involved in cell differentiation; cell population proliferation; and regulation of cell cycle. Located in Ino80 complex; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

796 residues, UniProt reviewed canonical sequence.

>Q9H869|YY1AP1
     1  MEEEASRSAA ATNPGSRLTR WPPPDKREGS AVDPGKRRSL AATPSSSLPC TLIALGLRHE
    61  KEANELMEDL FETFQDEMGF SNMEDDGPEE EERVAEPQAN FNTPQALRFE ELLANLLNEQ
   121  HQIAKELFEQ LKMKKPSAKQ QKEVEKVKPQ CKEVHQTLIL DPAQRKRLQQ QMQQHVQLLT
   181  QIHLLATCNP NLNPEASSTR ICLKELGTFA QSSIALHHQY NPKFQTLFQP CNLMGAMQLI
   241  EDFSTHVSID CSPHKTVKKT ANEFPCLPKQ VAWILATSKV FMYPELLPVC SLKAKNPQDK
   301  ILFTKAEDNK YLLTCKTARQ LTVRIKNLNM NRAPDNIIKF YKKTKQLPVL GKCCEEIQPH
   361  QWKPPIEREE HRLPFWLKAS LPSIQEELRH MADGAREVGN MTGTTEINSD QGLEKDNSEL
   421  GSETRYPLLL PKGVVLKLKP VADRFPKKAW RQKRSSVLKP LLIQPSPSLQ PSFNPGKTPA
   481  QSTHSEAPPS KMVLRIPHPI QPATVLQTVP GVPPLGVSGG ESFESPAALP AMPPEARTSF
   541  PLSESQTLLS SAPVPKVMMP SPASSMFRKP YVRRRPSKRR GARAFRCIKP APVIHPASVI
   601  FTVPATTVKI VSLGGGCNMI QPVNAAVAQS PQTIPIATLL VNPTSFPCPL NQPLVASSVS
   661  PLIVSGNSVN LPIPSTPEDK AHMNVDIACA VADGENAFQG LEPKLEPQEL SPLSATVFPK
   721  VEHSPGPPPV DKQCQEGLSE NSAYRWTVVK TEEGRQALEP LPQGIQESLN NSSPGDLEEV
   781  VKMEPEDATE EISGFL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against YY1AP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.58
Highest tissue expression: 108 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 108 nTPM
bone marrow: 73 nTPM
testis: 71 nTPM
tongue: 68 nTPM
blood vessel: 56 nTPM
colon: 54 nTPM

Single-cell type

neutrophils: 127 nCPM
myonuclei: 122 nCPM
neutrophil progenitors: 110 nCPM
esophageal apical cells: 89 nCPM
cone photoreceptor cells: 89 nCPM
cardiomyocytes: 86 nCPM

Immune cell

eosinophil: 51 nTPM
NK-cell: 45 nTPM
basophil: 40 nTPM
T-reg: 40 nTPM
MAIT T-cell: 37 nTPM
memory CD8 T-cell: 36 nTPM

Brain region

cerebellum: 93 nTPM
cerebral cortex: 75 nTPM
white matter: 72 nTPM
thalamus: 70 nTPM
basal ganglia: 66 nTPM
midbrain: 62 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about YY1AP1.

Disease | AllUniProt

Conditions YY1AP1 is implicated in, by any mechanism.

Grange syndrome (GRNG) MIM:602531

Disease | GeneticClinVar

15 pathogenic / likely-pathogenic of 219 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Grange syndrome
YY1AP1-related disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.31
gnomAD pLI: 0
gnomAD missense Z: -1.18
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 19% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

YY1-Associated Transcriptional Regulator

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of YY1AP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads YY1AP1 as an antibody target. Whether an autoantibody or antibody against YY1AP1 could matter depends on whether native YY1AP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

YY1AP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label YY1AP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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