Seroatlas · Human Serome Atlas

GABARAP

Gamma-aminobutyric acid receptor-associated protein

Also known as: ATG8A, GBRAP_HUMAN, MM46

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O95166
Gene
GABARAP
Ensembl
ENSG00000170296
Chromosome
17
Canonical length
117 aa
Protein class
Predicted intracellular proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

Gamma-aminobutyric acid A receptors [GABA(A) receptors] are ligand-gated chloride channels that mediate inhibitory neurotransmission. This gene encodes GABA(A) receptor-associated protein, which is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. This protein clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

117 residues, UniProt reviewed canonical sequence.

>O95166|GABARAP
     1  MKFVYKEEHP FEKRRSEGEK IRKKYPDRVP VIVEKAPKAR IGDLDKKKYL VPSDLTVGQF
    61  YFLIRKRIHL RAEDALFFFV NNVIPPTSAT MGQLYQEHHE EDFFLYIAYS DESVYGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GABARAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.29
Highest tissue expression
1,113 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 1,113 nTPM
  • skeletal muscle: 935 nTPM
  • spinal cord: 872 nTPM
  • tongue: 854 nTPM
  • pituitary gland: 815 nTPM
  • adrenal gland: 802 nTPM

Single-cell type

  • parietal cells: 371 nCPM
  • gastric chief cells: 341 nCPM
  • enterocytes: 335 nCPM
  • colonocytes: 268 nCPM
  • neuroendocrine cells: 253 nCPM
  • goblet cells: 247 nCPM

Immune cell

  • neutrophil: 7,142 nTPM
  • total PBMC: 4,751 nTPM
  • classical monocyte: 4,105 nTPM
  • eosinophil: 3,759 nTPM
  • intermediate monocyte: 3,673 nTPM
  • non-classical monocyte: 3,231 nTPM

Brain region

  • white matter: 553 nTPM
  • medulla oblongata: 485 nTPM
  • cerebellum: 484 nTPM
  • spinal cord: 469 nTPM
  • hypothalamus: 451 nTPM
  • thalamus: 444 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about GABARAP.

Disease | AutoantibodyPubMed

Conditions in which antibodies against GABARAP are reported. Each links to that disease's full target list.

ReferencesPubMed · IEDB

Publications for GABARAP from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

3 publications

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.82
gnomAD pLI
0.26
gnomAD missense Z
1.55
DepMap mean gene effect
-0.23
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GABARAP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GABARAP as an antibody target. Whether an autoantibody or antibody against GABARAP could matter depends on whether native GABARAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GABARAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GABARAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/GABARAP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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