Seroatlas · Human Serome Atlas

COPS8

COP9 signalosome complex subunit 8

Also known as: COP9, CSN8, CSN8_HUMAN, MGC1297, SGN8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q99627
Gene: COPS8
Ensembl: ENSG00000198612
Chromosome: 2
Canonical length: 209 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

209 residues, UniProt reviewed canonical sequence.

>Q99627|COPS8
     1  MPVAVMAESA FSFKKLLDQC ENQELEAPGG IATPPVYGQL LALYLLHNDM NNARYLWKRI
    61  PPAIKSANSE LGGIWSVGQR IWQRDFPGIY TTINAHQWSE TVQPIMEALR DATRRRAFAL
   121  VSQAYTSIIA DDFAAFVGLP VEEAVKGILE QGWQADSTTR MVLPRKPVAG ALDVSFNKFI
   181  PLSEPAPVPP IPNEQQLARL TDYVAFLEN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against COPS8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 160 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 160 nTPM
tongue: 110 nTPM
retina: 85 nTPM
heart muscle: 78 nTPM
cerebral cortex: 69 nTPM
hypothalamus: 66 nTPM

Single-cell type

oocytes: 1,110 nCPM
decidual stromal cells: 201 nCPM
differentiating spermatogonia: 187 nCPM
melanocytes: 171 nCPM
hepatic stellate cells: 129 nCPM
ovarian stromal cells: 120 nCPM

Immune cell

NK-cell: 72 nTPM
MAIT T-cell: 71 nTPM
T-reg: 71 nTPM
total PBMC: 71 nTPM
memory B-cell: 69 nTPM
memory CD8 T-cell: 66 nTPM

Brain region

hypothalamus: 100 nTPM
hippocampal formation: 74 nTPM
thalamus: 74 nTPM
cerebral cortex: 73 nTPM
white matter: 72 nTPM
pons: 72 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.49
gnomAD pLI: 0.72
gnomAD missense Z: 0.92
DepMap mean gene effect: -1.05
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of COPS8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads COPS8 as an antibody target. Whether an autoantibody or antibody against COPS8 could matter depends on whether native COPS8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

COPS8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label COPS8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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