Seroatlas · Human Serome Atlas

FEM1B

Protein fem-1 homolog B

Also known as: FEM1B_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UK73
Gene: FEM1B
Ensembl: ENSG00000169018
Chromosome: 15
Canonical length: 627 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol
Quaternary structure: Homooligomer

OverviewNCBI Gene

This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]

Canonical amino-acid sequenceUniProt

627 residues, UniProt reviewed canonical sequence.

>Q9UK73|FEM1B
     1  MEGLAGYVYK AASEGKVLTL AALLLNRSES DIRYLLGYVS QQGGQRSTPL IIAARNGHAK
    61  VVRLLLEHYR VQTQQTGTVR FDGYVIDGAT ALWCAAGAGH FEVVKLLVSH GANVNHTTVT
   121  NSTPLRAACF DGRLDIVKYL VENNANISIA NKYDNTCLMI AAYKGHTDVV RYLLEQRADP
   181  NAKAHCGATA LHFAAEAGHI DIVKELIKWR AAIVVNGHGM TPLKVAAESC KADVVELLLS
   241  HADCDRRSRI EALELLGASF ANDRENYDII KTYHYLYLAM LERFQDGDNI LEKEVLPPIH
   301  AYGNRTECRN PQELESIRQD RDALHMEGLI VRERILGADN IDVSHPIIYR GAVYADNMEF
   361  EQCIKLWLHA LHLRQKGNRN THKDLLRFAQ VFSQMIHLNE TVKAPDIECV LRCSVLEIEQ
   421  SMNRVKNISD ADVHNAMDNY ECNLYTFLYL VCISTKTQCS EEDQCKINKQ IYNLIHLDPR
   481  TREGFTLLHL AVNSNTPVDD FHTNDVCSFP NALVTKLLLD CGAEVNAVDN EGNSALHIIV
   541  QYNRPISDFL TLHSIIISLV EAGAHTDMTN KQNKTPLDKS TTGVSEILLK TQMKMSLKCL
   601  AARAVRANDI NYQDQIPRTL EEFVGFH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against FEM1B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.24
Highest tissue expression: 68 nTPM

Expression across tissuesHPA

Tissue

testis: 68 nTPM
bone marrow: 57 nTPM
skeletal muscle: 46 nTPM
smooth muscle: 28 nTPM
tongue: 26 nTPM
cerebral cortex: 25 nTPM

Single-cell type

early spermatids: 900 nCPM
late primary spermatocytes: 378 nCPM
late spermatids: 365 nCPM
suprabasal keratinocytes: 113 nCPM
thymic myoid cells: 112 nCPM
melanocytes: 104 nCPM

Immune cell

intermediate monocyte: 4.2 nTPM
NK-cell: 3.7 nTPM
non-classical monocyte: 3.6 nTPM
naive CD4 T-cell: 3.5 nTPM
memory CD8 T-cell: 3.3 nTPM
classical monocyte: 3.1 nTPM

Brain region

white matter: 70 nTPM
cerebellum: 68 nTPM
cerebral cortex: 59 nTPM
basal ganglia: 58 nTPM
pons: 58 nTPM
hypothalamus: 55 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about FEM1B.

Disease | AllUniProt

Conditions FEM1B is implicated in, by any mechanism.

Neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities (NEDBES) MIM:621263

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 51 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with behavioral, ear, and skeletal abnormalities

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.52
gnomAD pLI: 0.35
gnomAD missense Z: 3.62
DepMap mean gene effect: -0.21
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of FEM1B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads FEM1B as an antibody target. Whether an autoantibody or antibody against FEM1B could matter depends on whether native FEM1B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

FEM1B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label FEM1B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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