IGFBP5

Protein identityUniProt · HPA

UniProt accession

P24593

Gene

IGFBP5

Ensembl

ENSG00000115461

Chromosome

2

Canonical length

272 aa

Protein class

Plasma proteins, Predicted secreted proteins

Subcellular location

Vesicles

Secretome location

Secreted to blood

OverviewNCBI Gene

Enables insulin-like growth factor I binding activity and receptor ligand activity. Involved in several processes, including cellular response to cAMP; regulation of smooth muscle cell migration; and regulation of smooth muscle cell proliferation. Part of insulin-like growth factor ternary complex. Biomarker of pulmonary fibrosis. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

272 residues, UniProt reviewed canonical sequence.

>P24593|IGFBP5
     1  MVLLTAVLLL LAAYAGPAQS LGSFVHCEPC DEKALSMCPP SPLGCELVKE PGCGCCMTCA
    61  LAEGQSCGVY TERCAQGLRC LPRQDEEKPL HALLHGRGVC LNEKSYREQV KIERDSREHE
   121  EPTTSEMAEE TYSPKIFRPK HTRISELKAE AVKKDRRKKL TQSKFVGGAE NTAHPRIISA
   181  PEMRQESEQG PCRRHMEASL QELKASPRMV PRAVYLPNCD RKGFYKRKQC KPSRGRKRGI
   241  CWCVDKYGMK LPGMEYVDGD FQCHTFDSSN VE

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IGFBP5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.48

Highest tissue expression

1,401 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.29

gnomAD pLI

0.96

gnomAD missense Z

1.63

DepMap mean gene effect

0.08

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• cellular response to cAMP
• female pregnancy
• glucose homeostasis
• hair follicle morphogenesis
• insulin-like growth factor receptor signaling pathway
• intracellular signal transduction
• lung alveolus development
• mammary gland involution
• negative regulation of cell migration
• negative regulation of growth
• negative regulation of insulin-like growth factor receptor signaling pathway
• negative regulation of osteoblast differentiation
• negative regulation of smooth muscle cell migration
• negative regulation of smooth muscle cell proliferation
• negative regulation of translation
• osteoblast differentiation
• positive regulation of insulin-like growth factor receptor signaling pathway
• positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• positive regulation of vascular associated smooth muscle cell migration
• positive regulation of vascular associated smooth muscle cell proliferation
• regulation of cell growth
• regulation of insulin-like growth factor receptor signaling pathway
• response to growth hormone
• signal transduction
• striated muscle cell differentiation
• type B pancreatic cell proliferation
• negative regulation of muscle tissue development
• negative regulation of skeletal muscle hypertrophy

Molecular functions

• fibronectin binding
• insulin-like growth factor I binding
• insulin-like growth factor II binding
• receptor ligand activity

Cellular components

• endoplasmic reticulum lumen
• extracellular region
• extracellular space
• insulin-like growth factor binding protein complex
• insulin-like growth factor ternary complex
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Thyroglobulin type-1
• Insulin-like growth factor-binding protein, IGFBP
• Growth factor receptor cysteine-rich domain superfamily
• Insulin-like growth factor binding protein, N-terminal, Cys-rich conserved site
• Insulin-like growth factor-binding protein family 1-6, chordata
• Thyroglobulin type-1 superfamily
• Thyroglobulin type-1 repeat
• Insulin-like growth factor binding protein
• Insulin-like growth factor binding protein 5

KeywordsUniProt

• Cytoplasm
• Disulfide bond
• Glycoprotein
• Growth factor binding
• Nucleus
• Phosphoprotein
• Secreted
• Signal

InteractionsUniProt · HPA

Protein binding partners of IGFBP5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CAV1
• IGF1
• NCL
• ROR1