Seroatlas · Human Serome Atlas

STK38

Serine/threonine-protein kinase 38

Also known as: NDR, NDR1, STK38_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q15208
Gene
STK38
Ensembl
ENSG00000112079
Chromosome
6
Canonical length
465 aa
Protein class
Enzymes, Predicted intracellular proteins
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]

Canonical amino-acid sequenceUniProt

465 residues, UniProt reviewed canonical sequence.

>Q15208|STK38
     1  MAMTGSTPCS SMSNHTKERV TMTKVTLENF YSNLIAQHEE REMRQKKLEK VMEEEGLKDE
    61  EKRLRRSAHA RKETEFLRLK RTRLGLEDFE SLKVIGRGAF GEVRLVQKKD TGHVYAMKIL
   121  RKADMLEKEQ VGHIRAERDI LVEADSLWVV KMFYSFQDKL NLYLIMEFLP GGDMMTLLMK
   181  KDTLTEEETQ FYIAETVLAI DSIHQLGFIH RDIKPDNLLL DSKGHVKLSD FGLCTGLKKA
   241  HRTEFYRNLN HSLPSDFTFQ NMNSKRKAET WKRNRRQLAF STVGTPDYIA PEVFMQTGYN
   301  KLCDWWSLGV IMYEMLIGYP PFCSETPQET YKKVMNWKET LTFPPEVPIS EKAKDLILRF
   361  CCEWEHRIGA PGVEEIKSNS FFEGVDWEHI RERPAAISIE IKSIDDTSNF DEFPESDILK
   421  PTVATSNHPE TDYKNKDWVF INYTYKRFEG LTARGAIPSY MKAAK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against STK38 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.28
Highest tissue expression
40 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 40 nTPM
  • colon: 38 nTPM
  • esophagus: 38 nTPM
  • rectum: 34 nTPM
  • spleen: 33 nTPM
  • lymph node: 32 nTPM

Single-cell type

  • neutrophils: 601 nCPM
  • neutrophil progenitors: 497 nCPM
  • tuft cells: 277 nCPM
  • salivary duct cells: 256 nCPM
  • nk-cells: 233 nCPM
  • salivary ionocytes: 226 nCPM

Immune cell

  • basophil: 92 nTPM
  • non-classical monocyte: 74 nTPM
  • neutrophil: 60 nTPM
  • NK-cell: 60 nTPM
  • total PBMC: 58 nTPM
  • gdT-cell: 57 nTPM

Brain region

  • cerebellum: 17 nTPM
  • choroid plexus: 16 nTPM
  • thalamus: 16 nTPM
  • medulla oblongata: 15 nTPM
  • hippocampal formation: 14 nTPM
  • white matter: 14 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.64
gnomAD pLI
0
gnomAD missense Z
2.12
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of STK38 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads STK38 as an antibody target. Whether an autoantibody or antibody against STK38 could matter depends on whether native STK38 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

STK38 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label STK38 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/STK38. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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