Seroatlas · Human Serome Atlas

CAVIN3

Caveolae-associated protein 3

Also known as: cavin-3, CAVN3_HUMAN, HSRBC, MGC20400, PRKCDBP, SRBC

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q969G5
Gene
CAVIN3
Ensembl
ENSG00000170955
Chromosome
11
Canonical length
261 aa
Protein class
Predicted intracellular proteins
Subcellular location
Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene was identified as a binding protein of the protein kinase C, delta (PRKCD). The expression of this gene in cultured cell lines is strongly induced by serum starvation. The expression of this protein was found to be down-regulated in various cancer cell lines, suggesting the possible tumor suppressor function of this protein. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

261 residues, UniProt reviewed canonical sequence.

>Q969G5|CAVIN3
     1  MRESALERGP VPEAPAGGPV HAVTVVTLLE KLASMLETLR ERQGGLARRQ GGLAGSVRRI
    61  QSGLGALSRS HDTTSNTLAQ LLAKAERVSS HANAAQERAV RRAAQVQRLE ANHGLLVARG
   121  KLHVLLFKEE GEVPASAFQK APEPLGPADQ SELGPEQLEA EVGESSDEEP VESRAQRLRR
   181  TGLQKVQSLR RALSGRKGPA APPPTPVKPP RLGPGRSAEA QPEAQPALEP TLEPEPPQDT
   241  EEDPGRPGAA EEALLQMESV A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAVIN3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.6
Highest tissue expression
292 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 292 nTPM
  • endometrium: 121 nTPM
  • cervix: 91 nTPM
  • colon: 82 nTPM
  • adipose tissue: 80 nTPM
  • urinary bladder: 78 nTPM

Single-cell type

  • late primary spermatocytes: 813 nCPM
  • vascular smooth muscle cells: 431 nCPM
  • decidual stromal cells: 296 nCPM
  • late spermatids: 292 nCPM
  • hepatic stellate cells: 291 nCPM
  • smooth muscle cells: 243 nCPM

Immune cell

  • myeloid DC: 43 nTPM
  • classical monocyte: 16 nTPM
  • T-reg: 6.1 nTPM
  • total PBMC: 5.9 nTPM
  • intermediate monocyte: 1.1 nTPM
  • memory CD4 T-cell: 0.8 nTPM

Brain region

  • choroid plexus: 18 nTPM
  • thalamus: 8 nTPM
  • pons: 7.1 nTPM
  • basal ganglia: 6.8 nTPM
  • medulla oblongata: 6.5 nTPM
  • amygdala: 6.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.81
gnomAD pLI
0
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAVIN3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAVIN3 as an antibody target. Whether an autoantibody or antibody against CAVIN3 could matter depends on whether native CAVIN3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAVIN3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAVIN3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAVIN3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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