Seroatlas · Human Serome Atlas

JUP

Junction plakoglobin

Also known as: CTNNG, DP3, DPIII, PDGB, PG, PKGB, PLAK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P14923
Gene
JUP
Ensembl
ENSG00000173801
Chromosome
17
Canonical length
745 aa
Protein class
Cancer-related genes, Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins
Subcellular location
Vesicles,Plasma membrane,Cell Junctions
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene; however, not all transcripts have been fully described. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

745 residues, UniProt reviewed canonical sequence.

>P14923|JUP
     1  MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG RQYTLKKTTT
    61  YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL LLATQVEGQA TNLQRLAEPS
   121  QLLKSAIVHL INYQDDAELA TRALPELTKL LNDEDPVVVT KAAMIVNQLS KKEASRRALM
   181  GSPQLVAAVV RTMQNTSDLD TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE
   241  SVLFYAITTL HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
   301  ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE AGGMQALGKH
   361  LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL SVDDVNVLTC ATGTLSNLTC
   421  NNSKNKTLVT QNSGVEALIH AILRAGDKDD ITEPAVCALR HLTSRHPEAE MAQNSVRLNY
   481  GIPAIVKLLN QPNQWPLVKA TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR
   541  HVAAGTQQPY TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
   601  QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF RISEDKNPDY
   661  RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT YRPMYSSDVP LDPLEMHMDM
   721  DGDYPIDTYS DGLRPPYPTA DHMLA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against JUP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
914 nTPM

Expression across tissuesHPA

Tissue

  • esophagus: 914 nTPM
  • skin: 887 nTPM
  • vagina: 414 nTPM
  • cervix: 336 nTPM
  • salivary gland: 209 nTPM
  • heart muscle: 139 nTPM

Single-cell type

  • esophageal apical cells: 2,248 nCPM
  • esophageal suprabasal cells: 1,556 nCPM
  • suprabasal keratinocytes: 998 nCPM
  • esophageal basal cells: 688 nCPM
  • ocular epithelial cells: 618 nCPM
  • urothelial cells: 525 nCPM

Immune cell

  • non-classical monocyte: 44 nTPM
  • eosinophil: 29 nTPM
  • intermediate monocyte: 23 nTPM
  • myeloid DC: 15 nTPM
  • memory B-cell: 14 nTPM
  • classical monocyte: 13 nTPM

Brain region

  • white matter: 67 nTPM
  • choroid plexus: 53 nTPM
  • basal ganglia: 43 nTPM
  • medulla oblongata: 43 nTPM
  • cerebellum: 42 nTPM
  • cerebral cortex: 40 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about JUP.

Disease | AllUniProt

Conditions JUP is implicated in, by any mechanism.

  • Naxos disease (NXD) MIM:601214
  • Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12) MIM:611528

Disease | GeneticClinVar

37 pathogenic / likely-pathogenic of 1,509 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Disease | ImmuneIEDB

Conditions an epitope on JUP was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
1.32
DepMap mean gene effect
-0.11
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of JUP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads JUP as an antibody target. Whether an autoantibody or antibody against JUP could matter depends on whether native JUP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

JUP is annotated at the cell surface, where native JUP is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label JUP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/JUP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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