Seroatlas · Human Serome Atlas

SPRY1

Protein sprouty homolog 1

Also known as: hSPRY1, SPY1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O43609
Gene
SPRY1
Ensembl
ENSG00000164056
Chromosome
4
Canonical length
319 aa
Protein class
Cancer-related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Involved in negative regulation of fibroblast growth factor receptor signaling pathway. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

319 residues, UniProt reviewed canonical sequence.

>O43609|SPRY1
     1  MDPQNQHGSG SSLVVIQQPS LDSRQRLDYE REIQPTAILS LDQIKAIRGS NEYTEGPSVV
    61  KRPAPRTAPR QEKHERTHEI IPINVNNNYE HRHTSHLGHA VLPSNARGPI LSRSTSTGSA
   121  ASSGSNSSAS SEQGLLGRSP PTRPVPGHRS ERAIRTQPKQ LIVDDLKGSL KEDLTQHKFI
   181  CEQCGKCKCG ECTAPRTLPS CLACNRQCLC SAESMVEYGT CMCLVKGIFY HCSNDDEGDS
   241  YSDNPCSCSQ SHCCSRYLCM GAMSLFLPCL LCYPPAKGCL KLCRRCYDWI HRPGCRCKNS
   301  NTVYCKLESC PSRGQGKPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SPRY1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
225 nTPM

Expression across tissuesHPA

Tissue

  • adipose tissue: 225 nTPM
  • breast: 149 nTPM
  • blood vessel: 109 nTPM
  • thyroid gland: 89 nTPM
  • fallopian tube: 84 nTPM
  • gallbladder: 79 nTPM

Single-cell type

  • vascular endothelial cells: 501 nCPM
  • leydig cells: 475 nCPM
  • myosatellite cells: 328 nCPM
  • mesothelial cells: 240 nCPM
  • innate lymphoid cells: 235 nCPM
  • pituicytes/fscs: 217 nCPM

Immune cell

  • naive B-cell: 61 nTPM
  • MAIT T-cell: 33 nTPM
  • memory B-cell: 30 nTPM
  • NK-cell: 14 nTPM
  • memory CD8 T-cell: 9.2 nTPM
  • eosinophil: 6.5 nTPM

Brain region

  • choroid plexus: 53 nTPM
  • cerebral cortex: 15 nTPM
  • hypothalamus: 15 nTPM
  • basal ganglia: 14 nTPM
  • cerebellum: 13 nTPM
  • hippocampal formation: 12 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about SPRY1.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 72 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-0.95
DepMap mean gene effect
0.13
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SPRY1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SPRY1 as an antibody target. Whether an autoantibody or antibody against SPRY1 could matter depends on whether native SPRY1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SPRY1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label SPRY1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SPRY1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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