Seroatlas · Human Serome Atlas

NEU3

Sialidase-3

Also known as: NEUR3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9UQ49
Gene: NEU3
Ensembl: ENSG00000162139
Chromosome: 11
Canonical length: 428 aa
Protein class: Enzymes, Metabolic proteins, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles

OverviewNCBI Gene

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

428 residues, UniProt reviewed canonical sequence.

>Q9UQ49|NEU3
     1  MEEVTTCSFN SPLFRQEDDR GITYRIPALL YIPPTHTFLA FAEKRSTRRD EDALHLVLRR
    61  GLRIGQLVQW GPLKPLMEAT LPGHRTMNPC PVWEQKSGCV FLFFICVRGH VTERQQIVSG
   121  RNAARLCFIY SQDAGCSWSE VRDLTEEVIG SELKHWATFA VGPGHGIQLQ SGRLVIPAYT
   181  YYIPSWFFCF QLPCKTRPHS LMIYSDDLGV TWHHGRLIRP MVTVECEVAE VTGRAGHPVL
   241  YCSARTPNRC RAEALSTDHG EGFQRLALSR QLCEPPHGCQ GSVVSFRPLE IPHRCQDSSS
   301  KDAPTIQQSS PGSSLRLEEE AGTPSESWLL YSHPTSRKQR VDLGIYLNQT PLEAACWSRP
   361  WILHCGPCGY SDLAALEEEG LFGCLFECGT KQECEQIAFR LFTHREILSH LQGDCTSPGR
   421  NPSQFKSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NEU3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.27
Highest tissue expression: 25 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 25 nTPM
bone marrow: 22 nTPM
tongue: 21 nTPM
testis: 15 nTPM
adrenal gland: 13 nTPM
thymus: 11 nTPM

Single-cell type

myonuclei: 90 nCPM
cone photoreceptor cells: 85 nCPM
adrenal cortex cells: 53 nCPM
early primary spermatocytes: 53 nCPM
thymic myoid cells: 42 nCPM
cardiomyocytes: 37 nCPM

Immune cell

classical monocyte: 2.6 nTPM
eosinophil: 2.4 nTPM
non-classical monocyte: 1.8 nTPM
myeloid DC: 1.5 nTPM
naive CD8 T-cell: 1.5 nTPM
neutrophil: 1.5 nTPM

Brain region

cerebral cortex: 50 nTPM
basal ganglia: 45 nTPM
white matter: 44 nTPM
hypothalamus: 41 nTPM
cerebellum: 40 nTPM
pons: 40 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.34
gnomAD pLI: 0
gnomAD missense Z: 0.1
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NEU3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NEU3 as an antibody target. Whether an autoantibody or antibody against NEU3 could matter depends on whether native NEU3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NEU3 is annotated at the cell surface, where native NEU3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label NEU3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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