Seroatlas · Human Serome Atlas

GLIPR2

Golgi-associated plant pathogenesis-related protein 1

Also known as: C9orf19, GAPR-1, GAPR1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H4G4
Gene: GLIPR2
Ensembl: ENSG00000122694
Chromosome: 9
Canonical length: 154 aa
Protein class: Plasma proteins, Predicted intracellular proteins
Subcellular location: Vesicles,Microtubules
Quaternary structure: Homodimer

OverviewNCBI Gene

Enables protein homodimerization activity. Involved in positive regulation of ERK1 and ERK2 cascade; positive regulation of epithelial cell migration; and positive regulation of epithelial to mesenchymal transition. Located in Golgi membrane. Biomarker of pancreatic ductal adenocarcinoma. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

154 residues, UniProt reviewed canonical sequence.

>Q9H4G4|GLIPR2
     1  MGKSASKQFH NEVLKAHNEY RQKHGVPPLK LCKNLNREAQ QYSEALASTR ILKHSPESSR
    61  GQCGENLAWA SYDQTGKEVA DRWYSEIKNY NFQQPGFTSG TGHFTAMVWK NTKKMGVGKA
   121  SASDGSSFVV ARYFPAGNVV NEGFFEENVL PPKK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against GLIPR2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.28
Highest tissue expression: 70 nTPM

Expression across tissuesHPA

Tissue

colon: 70 nTPM
bone marrow: 70 nTPM
endometrium: 66 nTPM
smooth muscle: 60 nTPM
lung: 59 nTPM
appendix: 50 nTPM

Single-cell type

neutrophils: 576 nCPM
breast lactating cells: 342 nCPM
monocytes: 285 nCPM
neutrophil progenitors: 211 nCPM
cdc: 194 nCPM
monocyte progenitors: 169 nCPM

Immune cell

neutrophil: 660 nTPM
eosinophil: 542 nTPM
total PBMC: 414 nTPM
classical monocyte: 362 nTPM
basophil: 270 nTPM
myeloid DC: 209 nTPM

Brain region

thalamus: 35 nTPM
white matter: 33 nTPM
medulla oblongata: 29 nTPM
spinal cord: 23 nTPM
basal ganglia: 22 nTPM
midbrain: 21 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.59
gnomAD pLI: 0
gnomAD missense Z: 0.31
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein homodimerization activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

Cysteine-rich secretory protein-related
CAP domain
Allergen V5/Tpx-1-related, conserved site
CAP superfamily
Cysteine-rich secretory protein family
Golgi-associated plant pathogenesis-related protein 1, SCP domain

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of GLIPR2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CAV1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads GLIPR2 as an antibody target. Whether an autoantibody or antibody against GLIPR2 could matter depends on whether native GLIPR2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

GLIPR2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label GLIPR2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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