Seroatlas · Human Serome Atlas

BMX

Cytoplasmic tyrosine-protein kinase BMX

Also known as: BMX_HUMAN, ETK, PSCTK3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51813
Gene: BMX
Ensembl: ENSG00000102010
Chromosome: X
Canonical length: 675 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a non-receptor tyrosine kinase belonging to the Tec kinase family. The protein contains a PH-like domain, which mediates membrane targeting by binding to phosphatidylinositol 3,4,5-triphosphate (PIP3), and a SH2 domain that binds to tyrosine-phosphorylated proteins and functions in signal transduction. The protein is implicated in several signal transduction pathways including the Stat pathway, and regulates differentiation and tumorigenicity of several types of cancer cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2016]

Canonical amino-acid sequenceUniProt

675 residues, UniProt reviewed canonical sequence.

>P51813|BMX
     1  MDTKSILEEL LLKRSQQKKK MSPNNYKERL FVLTKTNLSY YEYDKMKRGS RKGSIEIKKI
    61  RCVEKVNLEE QTPVERQYPF QIVYKDGLLY VYASNEESRS QWLKALQKEI RGNPHLLVKY
   121  HSGFFVDGKF LCCQQSCKAA PGCTLWEAYA NLHTAVNEEK HRVPTFPDRV LKIPRAVPVL
   181  KMDAPSSSTT LAQYDNESKK NYGSQPPSSS TSLAQYDSNS KKIYGSQPNF NMQYIPREDF
   241  PDWWQVRKLK SSSSSEDVAS SNQKERNVNH TTSKISWEFP ESSSSEEEEN LDDYDWFAGN
   301  ISRSQSEQLL RQKGKEGAFM VRNSSQVGMY TVSLFSKAVN DKKGTVKHYH VHTNAENKLY
   361  LAENYCFDSI PKLIHYHQHN SAGMITRLRH PVSTKANKVP DSVSLGNGIW ELKREEITLL
   421  KELGSGQFGV VQLGKWKGQY DVAVKMIKEG SMSEDEFFQE AQTMMKLSHP KLVKFYGVCS
   481  KEYPIYIVTE YISNGCLLNY LRSHGKGLEP SQLLEMCYDV CEGMAFLESH QFIHRDLAAR
   541  NCLVDRDLCV KVSDFGMTRY VLDDQYVSSV GTKFPVKWSA PEVFHYFKYS SKSDVWAFGI
   601  LMWEVFSLGK QPYDLYDNSQ VVLKVSQGHR LYRPHLASDT IYQIMYSCWH ELPEKRPTFQ
   661  QLLSSIEPLR EKDKH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMX can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 97 nTPM

Expression across tissuesHPA

Tissue

epididymis: 97 nTPM
heart muscle: 8.6 nTPM
adipose tissue: 7.5 nTPM
bone marrow: 6.7 nTPM
breast: 4.8 nTPM
blood vessel: 4.7 nTPM

Single-cell type

tuft cells: 1,038 nCPM
cardiomyocytes: 247 nCPM
epididymal principal cells: 202 nCPM
neutrophil progenitors: 166 nCPM
neutrophils: 163 nCPM
lymphatic endothelial cells: 93 nCPM

Immune cell

neutrophil: 7.6 nTPM
basophil: 0.4 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

choroid plexus: 1.9 nTPM
basal ganglia: 0.7 nTPM
cerebral cortex: 0.6 nTPM
midbrain: 0.4 nTPM
pons: 0.4 nTPM
thalamus: 0.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.56
gnomAD pLI: 0.01
gnomAD missense Z: 0.99
DepMap mean gene effect: 0.19
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BMX in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMX as an antibody target. Whether an autoantibody or antibody against BMX could matter depends on whether native BMX is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMX is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BMX as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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