Seroatlas · Human Serome Atlas

IFITM1

Interferon-induced transmembrane protein 1

Also known as: 9-27, CD225, DSPA2a, IFI17, IFM1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P13164
Gene: IFITM1
Ensembl: ENSG00000185885
Chromosome: 11
Canonical length: 125 aa
Protein class: CD markers, Plasma proteins, Predicted membrane proteins, Transporters
Subcellular location: Golgi apparatus,Plasma membrane

OverviewNCBI Gene

Interferon-induced transmembrane (IFITM) proteins are a family of interferon induced antiviral proteins. The family contains five members, including IFITM1, IFITM2 and IFITM3 that belong to the CD225 superfamily. The protein encoded by this gene restricts cellular entry by diverse viral pathogens, such as influenza A virus, Ebola virus and Sars-CoV-2. [provided by RefSeq, Nov 2021]

Canonical amino-acid sequenceUniProt

125 residues, UniProt reviewed canonical sequence.

>P13164|IFITM1
     1  MHKEEHEVAV LGPPPSTILP RSTVINIHSE TSVPDHVVWS LFNTLFLNWC CLGFIAFAYS
    61  VKSRDRKMVG DVTGAQAYAS TAKCLNIWAL ILGILMTIGF ILLLVFGSVT VYHIMLQIIQ
   121  EKRGY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against IFITM1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 1,087 nTPM

Expression across tissuesHPA

Tissue

epididymis: 1,087 nTPM
spleen: 987 nTPM
ovary: 914 nTPM
choroid plexus: 896 nTPM
cervix: 733 nTPM
fallopian tube: 731 nTPM

Single-cell type

epididymal efferent duct absorptive cells: 358 nCPM
endometrial secretory cells: 264 nCPM
epididymal principal cells: 251 nCPM
neutrophils: 238 nCPM
leydig cells: 177 nCPM
ovarian stromal cells: 173 nCPM

Immune cell

NK-cell: 4,695 nTPM
total PBMC: 4,686 nTPM
memory CD4 T-cell: 3,132 nTPM
naive CD8 T-cell: 3,007 nTPM
memory CD8 T-cell: 3,002 nTPM
naive CD4 T-cell: 2,950 nTPM

Brain region

medulla oblongata: 171 nTPM
pons: 167 nTPM
choroid plexus: 162 nTPM
thalamus: 158 nTPM
spinal cord: 139 nTPM
cerebral cortex: 134 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0.14
gnomAD missense Z: 0.23
DepMap mean gene effect: 0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of IFITM1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads IFITM1 as an antibody target. Whether an autoantibody or antibody against IFITM1 could matter depends on whether native IFITM1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

IFITM1 is annotated at the cell surface, where native IFITM1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label IFITM1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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