SPRY3
Protein sprouty homolog 3
Also known as: HSPRY3, SPY3_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O43610
- Gene
- SPRY3
- Ensembl
- ENSG00000168939
- Chromosome
- X
- Canonical length
- 288 aa
- Protein class
- Predicted membrane proteins
- Subcellular location
- Nucleoli,Cytosol
OverviewNCBI Gene
Involved in negative regulation of MAPK cascade. Predicted to be located in cytoplasm and membrane. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
288 residues, UniProt reviewed canonical sequence.
>O43610|SPRY3
1 MDAAVTDDFQ QILPIEQLRS THASNDYVER PPAPCKQALS SPSLIVQTHK SDWSLATMPT
61 SLPRSLSQCH QLQPLPQHLS QSSIASSMSH STTASDQRLL ASITPSPSGQ SIIRTQPGAG
121 VHPKADGALK GEAEQSAGHP SEHLFICEEC GRCKCVPCTA ARPLPSCWLC NQRCLCSAES
181 LLDYGTCLCC VKGLFYHCST DDEDNCADEP CSCGPSSCFV RWAAMSLISL FLPCLCCYLP
241 TRGCLHLCQQ GYDSLRRPGC RCKRHTNTVC RKISSGSAPF PKAQEKSVLocalizationUniProt · AlphaFold · HPA
Whether an antibody against SPRY3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.56
- Highest tissue expression
- 4.2 nTPM
Expression across tissuesHPA
Tissue
- cerebellum: 4.2 nTPM
- epididymis: 2.5 nTPM
- bone marrow: 1.5 nTPM
- ovary: 1.5 nTPM
- adrenal gland: 1.3 nTPM
- retina: 1.3 nTPM
Single-cell type
- cardiomyocytes: 743 nCPM
- myonuclei: 301 nCPM
- neutrophil progenitors: 203 nCPM
- endometrial ciliated cells: 163 nCPM
- neutrophils: 154 nCPM
- endometrial luminal cells: 126 nCPM
Immune cell
- basophil: 0.1 nTPM
- neutrophil: 0.1 nTPM
- NK-cell: 0.1 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
- gdT-cell: 0 nTPM
Brain region
- cerebellum: 17 nTPM
- pons: 10 nTPM
- medulla oblongata: 9.8 nTPM
- cerebral cortex: 9.1 nTPM
- thalamus: 8.8 nTPM
- hippocampal formation: 8.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.15
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.02
- DepMap mean gene effect
- 0.1
- DepMap dependency class
- none
OntologyGO
Biological processes
- animal organ development
- negative regulation of ERK1 and ERK2 cascade
- negative regulation of fibroblast growth factor receptor signaling pathway
- negative regulation of MAPK cascade
- negative regulation of Ras protein signal transduction
- nervous system development
- negative regulation of neuron projection arborization
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SPRY3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SPRY3 as an antibody target. Whether an autoantibody or antibody against SPRY3 could matter depends on whether native SPRY3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SPRY3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label SPRY3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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