Seroatlas · Human Serome Atlas

ATG14

Beclin 1-associated autophagy-related key regulator

Also known as: ATG14L, BAKOR_HUMAN, KIAA0831

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6ZNE5
Gene
ATG14
Ensembl
ENSG00000126775
Chromosome
14
Canonical length
492 aa
Protein class
Predicted intracellular proteins, Transporters
Quaternary structure
Homooligomer

OverviewNCBI Gene

Enables GTPase binding activity; phosphatidylinositol 3-kinase inhibitor activity; and protein-membrane adaptor activity. Involved in several processes, including early endosome to late endosome transport; macroautophagy; and phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within endosome to lysosome transport. Located in autophagosome and phagophore assembly site membrane. Is extrinsic component of omegasome membrane and extrinsic component of phagophore assembly site membrane. Part of phosphatidylinositol 3-kinase complex, class III. Is active in phagophore assembly site. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

492 residues, UniProt reviewed canonical sequence.

>Q6ZNE5|ATG14
     1  MASPSGKGAR ALEAPGCGPR PLARDLVDSV DDAEGLYVAV ERCPLCNTTR RRLTCAKCVQ
    61  SGDFVYFDGR DRERFIDKKE RLSRLKSKQE EFQKEVLKAM EGKWITDQLR WKIMSCKMRI
   121  EQLKQTICKG NEEMEKNSEG LLKTKEKNQK LYSRAQRHQE KKEKIQRHNR KLGDLVEKKT
   181  IDLRSHYERL ANLRRSHILE LTSVIFPIEE VKTGVRDPAD VSSESDSAMT SSTVSKLAEA
   241  RRTTYLSGRW VCDDHNGDTS ISITGPWISL PNNGDYSAYY SWVEEKKTTQ GPDMEQSNPA
   301  YTISAALCYA TQLVNILSHI LDVNLPKKLC NSEFCGENLS KQKFTRAVKK LNANILYLCF
   361  SQHVNLDQLQ PLHTLRNLMY LVSPSSEHLG RSGPFEVRAD LEESMEFVDP GVAGESDESG
   421  DERVSDEETD LGTDWENLPS PRFCDIPSQS VEVSQSQSTQ ASPPIASSSA GGMISSAAAS
   481  VTSWFKAYTG HR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATG14 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.47
Highest tissue expression
27 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 27 nTPM
  • skeletal muscle: 15 nTPM
  • tongue: 9.7 nTPM
  • blood vessel: 9.6 nTPM
  • skin: 8.8 nTPM
  • retina: 8.2 nTPM

Single-cell type

  • myonuclei: 187 nCPM
  • cardiomyocytes: 155 nCPM
  • adipocytes: 102 nCPM
  • esophageal apical cells: 95 nCPM
  • undifferentiated spermatogonia: 87 nCPM
  • thymic myoid cells: 86 nCPM

Immune cell

  • NK-cell: 5.9 nTPM
  • naive B-cell: 2.8 nTPM
  • basophil: 2.7 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • classical monocyte: 2.5 nTPM
  • naive CD4 T-cell: 2.5 nTPM

Brain region

  • white matter: 15 nTPM
  • cerebellum: 12 nTPM
  • basal ganglia: 12 nTPM
  • cerebral cortex: 11 nTPM
  • medulla oblongata: 10 nTPM
  • spinal cord: 10 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.47
gnomAD pLI
0.17
gnomAD missense Z
0.55
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATG14 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATG14 as an antibody target. Whether an autoantibody or antibody against ATG14 could matter depends on whether native ATG14 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATG14 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ATG14 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ATG14. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...