Seroatlas · Human Serome Atlas

WDR91

WD repeat-containing protein 91

Also known as: HSPC049, SORF-1, WDR91_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D1P6
Gene: WDR91
Ensembl: ENSG00000105875
Chromosome: 7
Canonical length: 747 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables phosphatidylinositol 3-kinase inhibitor activity. Involved in early endosome to late endosome transport and regulation of protein catabolic process. Located in cytosol; early endosome membrane; and late endosome membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

747 residues, UniProt reviewed canonical sequence.

>A4D1P6|WDR91
     1  MAEAVERTDE LVREYLLFRG FTHTLRQLDA EIKADKEKGF RVDKIVDQLQ QLMQVYDLAA
    61  LRDYWSYLER RLFSRLEDIY RPTIHKLKTS LFRFYLVYTI QTNRNDKAQE FFAKQATELQ
   121  NQAEWKDWFV LPFLPSPDTN PTFATYFSRQ WADTFIVSLH NFLSVLFQCM PVPVILNFDA
   181  ECQRTNQVQE ENEVLRQKLF ALQAEIHRLK KEEQQPEEEE ALVQHKLPPY VSNMDRLGDS
   241  ELAMVCSQRN ASLSQSPRVG FLSSLLPQSK KSPSRLSPAQ GPPQPQSSAK KESFGGQGTK
   301  GKDPTSGAKD GKSLLSGLAT GESGWSQHRQ RRLQDHGKER KELFSTTTSQ CAEKKPEASG
   361  PEAEPCPELH TEPVEPLTRA SSAGPEGGGV RPEQPFIVLG QEEYGEHHSS IMHCRVDCSG
   421  RRVASLDVDG VIKVWSFNPI MQTKASSISK SPLLSLEWAT KRDRLLLLGS GVGTVRLYDT
   481  EAKKNLCEIN INDNMPRILS LACSPNGASF VCSAAAPSLT SQVDFSAPDI GSKGMNQVPG
   541  RLLLWDTKTM KQQLQFSLDP EPIAINCTAF NHNGNLLVTG AADGVIRLFD MQQHECAMSW
   601  RAHYGEVYSV EFSYDENTVY SIGEDGKFIQ WNIHKSGLKV SEYSLPSDAT GPFVLSGYSG
   661  YKQVQVPRGR LFAFDSEGNY MLTCSATGGV IYKLGGDEKV LESCLSLGGH RAPVVTVDWS
   721  TAMDCGTCLT ASMDGKIKLT TLLAHKA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WDR91 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 18 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 18 nTPM
pancreas: 7.4 nTPM
kidney: 6.4 nTPM
fallopian tube: 4.8 nTPM
placenta: 3.6 nTPM
spleen: 3.1 nTPM

Single-cell type

late spermatids: 95 nCPM
hofbauer cells: 85 nCPM
distal convoluted tubule cells: 80 nCPM
choroid plexus epithelial cells: 76 nCPM
renal connecting tubule cells: 62 nCPM
early spermatids: 62 nCPM

Immune cell

classical monocyte: 2.1 nTPM
eosinophil: 1.6 nTPM
naive CD4 T-cell: 1.6 nTPM
NK-cell: 1.3 nTPM
naive CD8 T-cell: 1.2 nTPM
memory B-cell: 1.1 nTPM

Brain region

choroid plexus: 23 nTPM
hippocampal formation: 8.8 nTPM
cerebral cortex: 8.5 nTPM
basal ganglia: 7.9 nTPM
white matter: 7.7 nTPM
cerebellum: 7.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about WDR91.

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 140 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Neurodevelopmental disorder with brain malformations and multiple congenital anomalies
See cases

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.62
gnomAD pLI: 0
gnomAD missense Z: 1.43
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

WD40 repeat
WD40/YVTN repeat-like-containing domain superfamily
WD40-repeat-containing domain superfamily
ARMC9, CTLH-like domain
WD domain, G-beta repeat
Armc9, CTLH-like domain
WD repeat-containing protein 91

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WDR91 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WDR91 as an antibody target. Whether an autoantibody or antibody against WDR91 could matter depends on whether native WDR91 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WDR91 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WDR91 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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