Seroatlas · Human Serome Atlas

ARMC3

Armadillo repeat-containing protein 3

Also known as: ARMC3_HUMAN, CT81, FLJ32827

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5W041
Gene: ARMC3
Ensembl: ENSG00000165309
Chromosome: 10
Canonical length: 872 aa
Protein class: Predicted intracellular proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Armadillo/beta-catenin (CTNNB1; MIM 116806)-like (ARM) domains are imperfect 45-amino acid repeats involved in protein-protein interactions. ARM domain-containing proteins, such as ARMC3, function in signal transduction, development, cell adhesion and mobility, and tumor initiation and metastasis (Li et al., 2006 [PubMed 16915934]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

872 residues, UniProt reviewed canonical sequence.

>Q5W041|ARMC3
     1  MGKKIKKEVE PPPKDVFDPL MIESKKAATV VLMLNSPEEE ILAKACEAIY KFALKGEENK
    61  TTLLELGAVE PLTKLLTHED KIVRRNATMI FGILASNNDV KKLLRELDVM NSVIAQLAPE
   121  EEVVIHEFAS LCLANMSAEY TSKVQIFEHG GLEPLIRLLS SPDPDVKKNS MECIYNLVQD
   181  FQCRAKLQEL NAIPPILDLL KSEYPVIQLL ALKTLGVIAN DKESRTMLRD NQGLDHLIKI
   241  LETKELNDLH IEALAVIANC LEDMDTMVQI QQTGGLKKLL SFAENSTIPD IQKNAAKAIT
   301  KAAYDPENRK LFHEQEVEKC LVALLGSEND GTKIAASQAI SAMCENSGSK DFFNNQGIPQ
   361  LIQLLKSDNE EVREAAALAL ANLTTCNPAN ANAAAEADGI DPLINLLSSK RDGAIANAAT
   421  VLTNMAMQEP LRLNIQNHDI MHAIISPLRS ANTVVQSKAA LAVTATACDV EARTELRNSG
   481  GLEPLVELLR SKNDEVRKHA SWAVMVCAGD ELTANELCRL GALDILEEVN VSGTRKNKFS
   541  EAAYNKLLNN NLSLKYSQTG YLSSSNIIND GFYDYGRINP GTKLLPLKEL CLQEPSDLRA
   601  VLLINSKSYV SPPSSMEDKS DVGYGRSISS SSSLRRSSKE KNKKNSYHFS AGFGSPIEDK
   661  SEPASGRNTV LSKSATKEKG WRKSKGKKEE EKVKEEEEVM VVPKFVGEGS SDKEWCPPSD
   721  PDFSMYVYEV TKSILPITNI KEQIEDLAKY VAEKMGGKIP KEKLPDFSWE LHISELKFQL
   781  KSNVIPIGHV KKGIFYHRAL LFKALADRIG IGCSLVRGEY GRAWNEVMLQ NDSRKGVIGG
   841  LPAPEMYVID LMFHPGGLMK LRSREADLYR FI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMC3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 49 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 49 nTPM
fallopian tube: 42 nTPM
testis: 31 nTPM
hypothalamus: 3.6 nTPM
basal ganglia: 3.4 nTPM
lung: 3.3 nTPM

Single-cell type

ependymal cells: 1,544 nCPM
choroid plexus epithelial cells: 996 nCPM
respiratory ciliated cells: 862 nCPM
fallopian tube ciliated cells: 732 nCPM
endometrial ciliated cells: 641 nCPM
epididymal efferent duct ciliated cells: 606 nCPM

Immune cell

total PBMC: 0.3 nTPM
MAIT T-cell: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM

Brain region

choroid plexus: 71 nTPM
midbrain: 27 nTPM
medulla oblongata: 24 nTPM
white matter: 17 nTPM
spinal cord: 16 nTPM
pons: 9.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.91
gnomAD pLI: 0
gnomAD missense Z: 0.91
DepMap mean gene effect: 0.15
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

extracellular exosome

Protein domainsUniProt · Pfam · InterPro

Armadillo
Armadillo-like helical
Armadillo-type fold
ARMC5-like, ARM-repeats domain
Armadillo/beta-catenin-like repeat
ARMC5
Armadillo Repeat & Ser/Thr Protein Kinase
EDR1/CTR1/ARMC3-like, peptidase-like domain
EDR1/CTR1/ARMC3, peptidase-like

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMC3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMC3 as an antibody target. Whether an autoantibody or antibody against ARMC3 could matter depends on whether native ARMC3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMC3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMC3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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