SH3BGRL
Adapter SH3BGRL
Also known as: MGC117402, SH3L1_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- O75368
- Gene
- SH3BGRL
- Ensembl
- ENSG00000131171
- Chromosome
- X
- Canonical length
- 114 aa
- Protein class
- Disease related genes, Plasma proteins, Predicted intracellular proteins
- Subcellular location
- Cytosol
OverviewNCBI Gene
Enables protein-RNA adaptor activity and ubiquitin-like ligase-substrate adaptor activity. Involved in positive regulation of cytoplasmic translational initiation and proteasome-mediated ubiquitin-dependent protein catabolic process. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
114 residues, UniProt reviewed canonical sequence.
>O75368|SH3BGRL
1 MVIRVYIASS SGSTAIKKKQ QDVLGFLEAN KIGFEEKDIA ANEENRKWMR ENVPENSRPA
61 TGYPLPPQIF NESQYRGDYD AFFEARENNA VYAFLGLTAP PGSKEAEVQA KQQALocalizationUniProt · AlphaFold · HPA
Whether an antibody against SH3BGRL can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.33
- Highest tissue expression
- 313 nTPM
Expression across tissuesHPA
Tissue
- blood vessel: 313 nTPM
- seminal vesicle: 268 nTPM
- smooth muscle: 216 nTPM
- endometrium: 195 nTPM
- colon: 182 nTPM
- bone marrow: 167 nTPM
Single-cell type
- platelets: 793 nCPM
- smooth muscle cells: 621 nCPM
- hofbauer cells: 615 nCPM
- kupffer cells: 542 nCPM
- vascular smooth muscle cells: 508 nCPM
- megakaryocytes: 439 nCPM
Immune cell
- basophil: 797 nTPM
- eosinophil: 572 nTPM
- non-classical monocyte: 563 nTPM
- intermediate monocyte: 477 nTPM
- total PBMC: 462 nTPM
- classical monocyte: 359 nTPM
Brain region
- white matter: 124 nTPM
- hypothalamus: 109 nTPM
- medulla oblongata: 102 nTPM
- spinal cord: 99 nTPM
- cerebellum: 85 nTPM
- pons: 82 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.17
- gnomAD pLI
- 0.3
- gnomAD missense Z
- 0.53
- DepMap mean gene effect
- 0.04
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
- positive regulation of cytoplasmic translational initiation
- proteasome-mediated ubiquitin-dependent protein catabolic process
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of SH3BGRL in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads SH3BGRL as an antibody target. Whether an autoantibody or antibody against SH3BGRL could matter depends on whether native SH3BGRL is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
SH3BGRL is annotated at the cell surface, where native SH3BGRL is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label SH3BGRL as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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