Seroatlas · Human Serome Atlas

WASH3P

Putative WAS protein family homolog 3

Also known as: WASH3_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
C4AMC7
Gene
WASH3P
Canonical length
463 aa

OverviewNCBI Gene

No narrative summary is available for WASH3P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

463 residues, UniProt reviewed canonical sequence.

>C4AMC7|WASH3P
     1  MTPVRMQHSL AGQTYAVPLI QPDLRREEAV QQMADALQYL QKVSGDIFSR ISQQVEQSRS
    61  QVQAIGEKVS LAQAKIEKIK GSKKAIKVFS SAKYPAPERL QEYGSIFTGA QDPGLQRRPR
   121  HRIQSKHRPL DERALQEKDF PVCVSTKPEP EDDAEEGLGG LPSNISSVSS LLLFNTTENL
   181  GKKYVFLDPL AGAVTKTHVM LGAETEEKLF DAPLSISKRE QLEQQVPENY FYVPDLGQVP
   241  EIDVPSYLPD LPGITNDLMY IADLGPGIAP SAPGTIPELP TFHTEVAEPL KVDLQDGVLT
   301  PPPPPPPPPP APEVLASAPP LPPSTAAPVG QGARQDDSSS SASPSVQGAP REVVDPSGGR
   361  ATLLESIRQA GGIGKAKLRS MKERKLEKKQ QKEQEQVRAT SQGGHLMSDL FNKLVMRRKG
   421  ISGKGPGAGE GPGGAFARVS DSIPPLPPPQ QPQAEEDEDD WES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against WASH3P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.62

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of WASH3P in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads WASH3P as an antibody target. Whether an autoantibody or antibody against WASH3P could matter depends on whether native WASH3P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

WASH3P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label WASH3P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/WASH3P. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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