Seroatlas · Human Serome Atlas

SLAMF1

Signaling lymphocytic activation molecule

Also known as: CD150, SLAF1_HUMAN, SLAM

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q13291
Gene
SLAMF1
Ensembl
ENSG00000117090
Chromosome
1
Canonical length
335 aa
Protein class
CD markers, Predicted membrane proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

Enables SH2 domain binding activity; identical protein binding activity; and virus receptor activity. Involved in several processes, including negative regulation of CD40 signaling pathway; negative regulation of cytokine production; and positive regulation of MAPK cascade. Located in extracellular exosome. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

335 residues, UniProt reviewed canonical sequence.

>Q13291|SLAMF1
     1  MDPKGLLSLT FVLFLSLAFG ASYGTGGRMM NCPKILRQLG SKVLLPLTYE RINKSMNKSI
    61  HIVVTMAKSL ENSVENKIVS LDPSEAGPPR YLGDRYKFYL ENLTLGIRES RKEDEGWYLM
   121  TLEKNVSVQR FCLQLRLYEQ VSTPEIKVLN KTQENGTCTL ILGCTVEKGD HVAYSWSEKA
   181  GTHPLNPANS SHLLSLTLGP QHADNIYICT VSNPISNNSQ TFSPWPGCRT DPSETKPWAV
   241  YAGLLGGVIM ILIMVVILQL RRRGKTNHYQ TTVEKKSLTI YAQVQKPGPL QKKLDSFPAQ
   301  DPCTTIYVAA TEPVPESVQE TNSITVYASV TLPES

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against SLAMF1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.45
Highest tissue expression
59 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 59 nTPM
  • lymph node: 17 nTPM
  • tonsil: 15 nTPM
  • appendix: 11 nTPM
  • urinary bladder: 7.1 nTPM
  • bone marrow: 5.8 nTPM

Single-cell type

  • plasma cells: 133 nCPM
  • t-cells: 94 nCPM
  • innate lymphoid cells: 55 nCPM
  • b-cells: 43 nCPM
  • monocytes: 43 nCPM
  • mast cells: 29 nCPM

Immune cell

  • MAIT T-cell: 51 nTPM
  • T-reg: 49 nTPM
  • memory CD4 T-cell: 36 nTPM
  • memory CD8 T-cell: 25 nTPM
  • naive B-cell: 18 nTPM
  • memory B-cell: 14 nTPM

Brain region

  • choroid plexus: 0.6 nTPM
  • medulla oblongata: 0.5 nTPM
  • hypothalamus: 0.2 nTPM
  • pons: 0.2 nTPM
  • spinal cord: 0.2 nTPM
  • thalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.8
gnomAD pLI
0.01
gnomAD missense Z
0.66
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of SLAMF1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads SLAMF1 as an antibody target. Whether an autoantibody or antibody against SLAMF1 could matter depends on whether native SLAMF1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

SLAMF1 is annotated at the cell surface, where native SLAMF1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label SLAMF1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/SLAMF1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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