Seroatlas · Human Serome Atlas

NRBF2

Nuclear receptor-binding factor 2

Also known as: COPR1, COPR2, DKFZp564C1664, FLJ30395, NRBF2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96F24
Gene: NRBF2
Ensembl: ENSG00000148572
Chromosome: 10
Canonical length: 287 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

Involved in autophagy. Located in cytoplasm and phosphatidylinositol 3-kinase complex, class III. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

287 residues, UniProt reviewed canonical sequence.

>Q96F24|NRBF2
     1  MEVMEGPLNL AHQQSRRADR LLAAGKYEEA ISCHKKAAAY LSEAMKLTQS EQAHLSLELQ
    61  RDSHMKQLLL IQERWKRAQR EERLKAQQNT DKDAAAHLQT SHKPSAEDAE GQSPLSQKYS
   121  PSTEKCLPEI QGIFDRDPDT LLYLLQQKSE PAEPCIGSKA PKDDKTIIEE QATKIADLKR
   181  HVEFLVAENE RLRKENKQLK AEKARLLKGP IEKELDVDAD FVETSELWSL PPHAETATAS
   241  STWQKFAANT GKAKDIPIPN LPPLDFPSPE LPLMELSEDI LKGFMNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against NRBF2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.54
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

liver: 42 nTPM
bone marrow: 32 nTPM
tongue: 25 nTPM
skeletal muscle: 24 nTPM
spleen: 21 nTPM
thymus: 21 nTPM

Single-cell type

neutrophils: 544 nCPM
syncytiotrophoblasts: 391 nCPM
esophageal apical cells: 133 nCPM
neutrophil progenitors: 103 nCPM
extravillous trophoblasts: 101 nCPM
breast lactating cells: 77 nCPM

Immune cell

neutrophil: 690 nTPM
eosinophil: 163 nTPM
basophil: 125 nTPM
non-classical monocyte: 94 nTPM
intermediate monocyte: 92 nTPM
classical monocyte: 80 nTPM

Brain region

pons: 21 nTPM
midbrain: 20 nTPM
medulla oblongata: 17 nTPM
thalamus: 16 nTPM
white matter: 16 nTPM
cerebellum: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.06
gnomAD pLI: 0
gnomAD missense Z: 0.28
DepMap mean gene effect: -0.3
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Nuclear receptor-binding factor 2, C-terminal
Nuclear receptor-binding factor 2, MIT domain
Nuclear receptor-binding factor 2
Nuclear receptor-binding factor 2, autophagy regulator
MIT domain of nuclear receptor-binding factor 2

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of NRBF2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads NRBF2 as an antibody target. Whether an autoantibody or antibody against NRBF2 could matter depends on whether native NRBF2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

NRBF2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label NRBF2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...