PIK3CB

Protein identityUniProt · HPA

UniProt accession

P42338

Gene

PIK3CB

Ensembl

ENSG00000051382

Chromosome

3

Canonical length

1070 aa

Protein class

Cancer-related genes, Enzymes, Metabolic proteins, Plasma proteins, Predicted intracellular proteins, RAS pathway related proteins

Subcellular location

Nucleoplasm,Nucleoli,Vesicles,Midbody

OverviewNCBI Gene

This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

Canonical amino-acid sequenceUniProt

1070 residues, UniProt reviewed canonical sequence.

>P42338|PIK3CB
     1  MCFSFIMPPA MADILDIWAV DSQIASDGSI PVDFLLPTGI YIQLEVPREA TISYIKQMLW
    61  KQVHNYPMFN LLMDIDSYMF ACVNQTAVYE ELEDETRRLC DVRPFLPVLK LVTRSCDPGE
   121  KLDSKIGVLI GKGLHEFDSL KDPEVNEFRR KMRKFSEEKI LSLVGLSWMD WLKQTYPPEH
   181  EPSIPENLED KLYGGKLIVA VHFENCQDVF SFQVSPNMNP IKVNELAIQK RLTIHGKEDE
   241  VSPYDYVLQV SGRVEYVFGD HPLIQFQYIR NCVMNRALPH FILVECCKIK KMYEQEMIAI
   301  EAAINRNSSN LPLPLPPKKT RIISHVWENN NPFQIVLVKG NKLNTEETVK VHVRAGLFHG
   361  TELLCKTIVS SEVSGKNDHI WNEPLEFDIN ICDLPRMARL CFAVYAVLDK VKTKKSTKTI
   421  NPSKYQTIRK AGKVHYPVAW VNTMVFDFKG QLRTGDIILH SWSSFPDELE EMLNPMGTVQ
   481  TNPYTENATA LHVKFPENKK QPYYYPPFDK IIEKAAEIAS SDSANVSSRG GKKFLPVLKE
   541  ILDRDPLSQL CENEMDLIWT LRQDCREIFP QSLPKLLLSI KWNKLEDVAQ LQALLQIWPK
   601  LPPREALELL DFNYPDQYVR EYAVGCLRQM SDEELSQYLL QLVQVLKYEP FLDCALSRFL
   661  LERALGNRRI GQFLFWHLRS EVHIPAVSVQ FGVILEAYCR GSVGHMKVLS KQVEALNKLK
   721  TLNSLIKLNA VKLNRAKGKE AMHTCLKQSA YREALSDLQS PLNPCVILSE LYVEKCKYMD
   781  SKMKPLWLVY NNKVFGEDSV GVIFKNGDDL RQDMLTLQML RLMDLLWKEA GLDLRMLPYG
   841  CLATGDRSGL IEVVSTSETI ADIQLNSSNV AAAAAFNKDA LLNWLKEYNS GDDLDRAIEE
   901  FTLSCAGYCV ASYVLGIGDR HSDNIMVKKT GQLFHIDFGH ILGNFKSKFG IKRERVPFIL
   961  TYDFIHVIQQ GKTGNTEKFG RFRQCCEDAY LILRRHGNLF ITLFALMLTA GLPELTSVKD
  1021  IQYLKDSLAL GKSEEEALKQ FKQKFDEALR ESWTTKVNWM AHTVRKDYRS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against PIK3CB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.25

Highest tissue expression

40 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about PIK3CB.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 139 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• NK-cell enteropathy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.25

gnomAD pLI

1

gnomAD missense Z

3.09

DepMap mean gene effect

-0.19

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• angiogenesis involved in wound healing
• autophagy
• cell migration
• cell surface receptor protein tyrosine kinase signaling pathway
• chemotaxis
• embryonic cleavage
• endocytosis
• endothelial cell proliferation
• G protein-coupled receptor signaling pathway
• homophilic cell adhesion via plasma membrane adhesion molecules
• intracellular calcium ion homeostasis
• natural killer cell mediated cytotoxicity
• negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway
• negative regulation of MAPK cascade
• negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
• negative regulation of sprouting angiogenesis
• negative regulation of vascular endothelial growth factor signaling pathway
• phosphatidylinositol 3-kinase/protein kinase B signal transduction
• phosphatidylinositol phosphate biosynthetic process
• phosphatidylinositol-3-phosphate biosynthetic process
• phosphatidylinositol-mediated signaling
• platelet activation
• platelet aggregation
• positive regulation of autophagy
• positive regulation of endothelial cell migration
• positive regulation of gene expression
• positive regulation of neutrophil apoptotic process
• positive regulation of nitric oxide biosynthetic process
• positive regulation of Rac protein signal transduction
• regulation of cell-matrix adhesion
• regulation of clathrin-dependent endocytosis
• response to ischemia
• signal transduction
• sphingosine-1-phosphate receptor signaling pathway

Molecular functions

• 1-phosphatidylinositol-3-kinase activity
• 1-phosphatidylinositol-4,5-bisphosphate 3-kinase activity
• 1-phosphatidylinositol-4-phosphate 3-kinase activity
• ATP binding
• insulin receptor substrate binding
• protein serine kinase activity
• protein serine/threonine kinase activity

Cellular components

• cytoplasm
• cytosol
• midbody
• nucleolus
• nucleoplasm
• nucleus
• phosphatidylinositol 3-kinase complex
• phosphatidylinositol 3-kinase complex, class IA
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
• Phosphatidylinositol 3-/4-kinase, catalytic domain
• Phosphoinositide 3-kinase, accessory (PIK) domain
• C2 phosphatidylinositol 3-kinase-type domain
• Phosphatidylinositol 3-kinase, adaptor-binding domain
• Protein kinase-like domain superfamily
• Phosphatidylinositol 3-/4-kinase
• Armadillo-type fold
• Phosphatidylinositol 3-/4-kinase, conserved site
• Ubiquitin-like domain superfamily
• C2 domain superfamily
• Phosphatidylinositol 3-/4-kinase, catalytic domain superfamily
• Phosphoinositide 3-kinase, accessory (PIK) domain superfamily
• Phosphatidylinositol 3- and 4-kinase
• Phosphoinositide 3-kinase family, accessory domain (PIK domain)
• Phosphoinositide 3-kinase C2
• PI3-kinase family, ras-binding domain
• PI3-kinase family, p85-binding domain
• Phosphatidylinositol 3-kinase beta, catalytic domain

KeywordsUniProt

• ATP-binding
• Autophagy
• Cell adhesion
• Cytoplasm
• Endocytosis
• Kinase
• Lipid metabolism
• Nucleotide-binding
• Nucleus
• Phosphoprotein
• Transferase

InteractionsUniProt · HPA

Protein binding partners of PIK3CB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ATG14
• BECN1
• RAB5A
• PIK3R1
• PIK3R2
• PIK3R3