Seroatlas · Human Serome Atlas

EXOC8

Exocyst complex component 8

Also known as: EXO84, Exo84p, EXOC8_HUMAN, SEC84

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IYI6
Gene
EXOC8
Ensembl
ENSG00000116903
Chromosome
1
Canonical length
725 aa
Protein class
Disease related genes, Human disease related genes, Potential drug targets, Predicted intracellular proteins, Transporters
Subcellular location
Cytosol

OverviewNCBI Gene

This gene encodes a component of the exocyst complex, an evolutionarily conserved multi-protein complex that plays a critical role in vesicular trafficking and the secretory pathway by targeting post-Golgi vesicles to the plasma membrane. This protein is a target of activated Ral subfamily of GTPases and thereby regulates exocytosis by tethering vesicles to the plasma membrane. Mutations in this gene may be related to Joubert syndrome. [provided by RefSeq, Sep 2016]

Canonical amino-acid sequenceUniProt

725 residues, UniProt reviewed canonical sequence.

>Q8IYI6|EXOC8
     1  MAMAMSDSGA SRLRRQLESG GFEARLYVKQ LSQQSDGDRD LQEHRQRIQA LAEETAQNLK
    61  RNVYQNYRQF IETAREISYL ESEMYQLSHL LTEQKSSLES IPLTLLPAAA AAGAAAASGG
   121  EEGVGGAGGR DHLRGQAGFF STPGGASRDG SGPGEEGKQR TLTTLLEKVE GCRHLLETPG
   181  QYLVYNGDLV EYDADHMAQL QRVHGFLMND CLLVATWLPQ RRGMYRYNAL YSLDGLAVVN
   241  VKDNPPMKDM FKLLMFPESR IFQAENAKIK REWLEVLEDT KRALSEKRRR EQEEAAAPRG
   301  PPQVTSKATN PFEDDEEEEP AVPEVEEEKV DLSMEWIQEL PEDLDVCIAQ RDFEGAVDLL
   361  DKLNHYLEDK PSPPPVKELR AKVEERVRQL TEVLVFELSP DRSLRGGPKA TRRAVSQLIR
   421  LGQCTKACEL FLRNRAAAVH TAIRQLRIEG ATLLYIHKLC HVFFTSLLET AREFEIDFAG
   481  TDSGCYSAFV VWARSAMGMF VDAFSKQVFD SKESLSTAAE CVKVAKEHCQ QLGDIGLDLT
   541  FIIHALLVKD IQGALHSYKE IIIEATKHRN SEEMWRRMNL MTPEALGKLK EEMKSCGVSN
   601  FEQYTGDDCW VNLSYTVVAF TKQTMGFLEE ALKLYFPELH MVLLESLVEI ILVAVQHVDY
   661  SLRCEQDPEK KAFIRQNASF LYETVLPVVE KRFEEGVGKP AKQLQDLRNA SRLIRVNPES
   721  TTSVV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against EXOC8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
16 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 16 nTPM
  • skeletal muscle: 13 nTPM
  • tongue: 9.2 nTPM
  • lymph node: 8.6 nTPM
  • tonsil: 8.6 nTPM
  • parathyroid gland: 8.2 nTPM

Single-cell type

  • neutrophils: 31 nCPM
  • thymic myoid cells: 19 nCPM
  • kupffer cells: 18 nCPM
  • medullary thymic epithelial cells: 17 nCPM
  • neutrophil progenitors: 16 nCPM
  • suprabasal keratinocytes: 15 nCPM

Immune cell

  • neutrophil: 2.2 nTPM
  • basophil: 1.7 nTPM
  • non-classical monocyte: 1.6 nTPM
  • eosinophil: 1.3 nTPM
  • naive CD8 T-cell: 1.2 nTPM
  • intermediate monocyte: 0.8 nTPM

Brain region

  • cerebellum: 18 nTPM
  • hypothalamus: 17 nTPM
  • cerebral cortex: 16 nTPM
  • white matter: 16 nTPM
  • pons: 15 nTPM
  • thalamus: 15 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about EXOC8.

Disease | AllUniProt

Conditions EXOC8 is implicated in, by any mechanism.

  • Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy (NEDMISB) MIM:619076

Disease | GeneticClinVar

2 pathogenic / likely-pathogenic of 106 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Neurodevelopmental disorder with microcephaly, seizures, and brain atrophy

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.19
gnomAD pLI
1
gnomAD missense Z
2.04
DepMap mean gene effect
-0.42
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 11% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of EXOC8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads EXOC8 as an antibody target. Whether an autoantibody or antibody against EXOC8 could matter depends on whether native EXOC8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

EXOC8 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label EXOC8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/EXOC8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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