Seroatlas · Human Serome Atlas

TAB3

TGF-beta-activated kinase 1 and MAP3K7-binding protein 3

Also known as: MAP3K7IP3, TAB3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8N5C8
Gene: TAB3
Ensembl: ENSG00000157625
Chromosome: X
Canonical length: 712 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nuclear speckles,Cytosol

OverviewNCBI Gene

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

712 residues, UniProt reviewed canonical sequence.

>Q8N5C8|TAB3
     1  MAQSSPQLDI QVLHDLRQRF PEIPEGVVSQ CMLQNNNNLE ACCRALSQES SKYLYMEYHS
    61  PDDNRMNRNR LLHINLGIHS PSSYHPGDGA QLNGGRTLVH SSSDGHIDPQ HAAGKQLICL
   121  VQEPHSAPAV VAATPNYNPF FMNEQNRSAA TPPSQPPQQP SSMQTGMNPS AMQGPSPPPP
   181  PPSYMHIPRY STNPITVTVS QNLPSGQTVP RALQILPQIP SNLYGSPGSI YIRQTSQSSS
   241  GRQTPQSTPW QSSPQGPVPH YSQRPLPVYP HQQNYQPSQY SPKQQQIPQS AYHSPPPSQC
   301  PSPFSSPQHQ VQPSQLGHIF MPPSPSTTPP HPYQQGPPSY QKQGSHSVAY LPYTASSLSK
   361  GSMKKIEITV EPSQRPGTAI NRSPSPISNQ PSPRNQHSLY TATTPPSSSP SRGISSQPKP
   421  PFSVNPVYIT YTQPTGPSCT PSPSPRVIPN PTTVFKITVG RATTENLLNL VDQEERSAAP
   481  EPIQPISVIP GSGGEKGSHK YQRSSSSGSD DYAYTQALLL HQRARMERLA KQLKLEKEEL
   541  ERLKSEVNGM EHDLMQRRLR RVSCTTAIPT PEEMTRLRSM NRQLQINVDC TLKEVDLLQS
   601  RGNFDPKAMN NFYDNIEPGP VVPPKPSKKD SSDPCTIERK ARRISVTSKV QADIHDTQAA
   661  AADEHRTGST QSPRTQPRDE DYEGAPWNCD SCTFLNHPAL NRCEQCEMPR YT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against TAB3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 26 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 26 nTPM
liver: 22 nTPM
retina: 21 nTPM
pancreas: 18 nTPM
endometrium: 15 nTPM
bone marrow: 14 nTPM

Single-cell type

sertoli cells: 259 nCPM
choroid plexus epithelial cells: 209 nCPM
esophageal apical cells: 139 nCPM
neutrophils: 84 nCPM
platelets: 69 nCPM
prostatic glandular cells: 68 nCPM

Immune cell

NK-cell: 0.9 nTPM
naive B-cell: 0.3 nTPM
eosinophil: 0.2 nTPM
intermediate monocyte: 0.2 nTPM
MAIT T-cell: 0.2 nTPM
memory B-cell: 0.2 nTPM

Brain region

choroid plexus: 36 nTPM
cerebral cortex: 16 nTPM
midbrain: 15 nTPM
hippocampal formation: 13 nTPM
medulla oblongata: 13 nTPM
white matter: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.42
gnomAD pLI: 0.62
gnomAD missense Z: 1.76
DepMap mean gene effect: 0.04
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of TAB3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads TAB3 as an antibody target. Whether an autoantibody or antibody against TAB3 could matter depends on whether native TAB3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

TAB3 is annotated at the cell surface, where native TAB3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label TAB3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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